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New GLP1 pill helps patients lose up to 8% of body weight, trial shows

Daily orforglipron tablets led to greater weight loss than semaglutide tablets, offering potential oral alternative to Wegovy and Mounjaro

A new daily pill could be a more effective GLP-1 tablet for weight loss, according to a clinical trial that may pave the way for a non-injection alternative to Wegovy and Mounjaro.

The drug, called orforglipron and manufactured by Eli Lilly, is prescribed for type 2 diabetes and targets the same GLP-1 receptors as oral semaglutide. Like semaglutide, it lowers blood sugar levels, slows digestion and suppresses appetite. However, unlike semaglutide tablets, it does not need to be taken on an empty stomach.

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© Photograph: Kumar Sriskandan/Alamy

© Photograph: Kumar Sriskandan/Alamy

© Photograph: Kumar Sriskandan/Alamy

Hillary Clinton to testify in House Oversight Committee’s Epstein investigation – US politics live

26 février 2026 à 12:29

Deposition will be filmed but take place behind closed doors, with former president Bill Clinton scheduled to answer questions tomorrow

At least 10 FBI employees connected to an investigation of Donald Trump have reportedly been dismissed following revelations that the agency subpoenaed personal records of current FBI director Kash Patel and White House chief of staff Susie Wiles in the years before Trump returned to office.

The ousters, reported by CBS News and CNN, were linked to the federal investigation led by former justice department special counsel Jack Smith into Trump’s alleged mishandling of classified documents that were found at his Florida Mar-a-Lago resort after his first term.

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© Photograph: Action Press/Shutterstock

© Photograph: Action Press/Shutterstock

© Photograph: Action Press/Shutterstock

Perfect for an apocalypse! How the nuclear bunker became TV’s hottest property

26 février 2026 à 12:00

With tech bros investing in vast underground homes to shield them from future horrors, a slew of ‘bunker-buster’ dramas like Paradise and Silo are asking: do they know something we don’t?

Sam Altman’s got one – although Mark Zuckerberg’s is, apparently, bigger. Peter Thiel’s is described as “mega” and located in New Zealand. These days, a doomsday bunker (or, in Elon Musk’s case, an “apocalypse resort”) is de rigueur for any self-respecting billionaire – enough to make you wonder if they know something we don’t.

A slew of recent dramas suggests that we are fascinated by such impressive underground real estate. Most audacious is Paradise on Disney+, in which tech-billionaire Samantha Redmond (Julianne Nicholson) funds a staggeringly elaborate building project under the not-so-subtle codename “Versailles”. Unlike Clive Owen’s Andy Ronson in A Murder at the End of the World, saving a few hand-picked individuals isn’t enough for this girl-boss-cum-tech-bro. Instead, Redmond has gone a step further, building “the world’s largest underground city”, an ersatz all-American suburb, accommodating 25,000 people while a climate catastrophe plays out above their heads.

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© Photograph: Landmark Media/Alamy

© Photograph: Landmark Media/Alamy

© Photograph: Landmark Media/Alamy

Workers decry Whirlpool’s job cuts amid offshoring, praise of Trump’s tariffs

26 février 2026 à 12:00

The US has lost factory jobs amid promises of a tariff-led renaissance

Workers at Whirlpool, the US’s largest appliance manufacturer and a champion of Donald Trump’s tariff policies, are criticizing the company for cutting jobs at an Iowa plant while bolstering production in Mexico.

The job cuts at Whirlpool come as the company has continued to support the Trump administration’s trade policies and claimed they will help bolster US manufacturing. Trump’s trade policies appear to have done little for US manufacturing so far. The US has lost 83,000 factory jobs since Trump took office in January 2025.

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© Photograph: Scott Olson/Getty Images

© Photograph: Scott Olson/Getty Images

© Photograph: Scott Olson/Getty Images

America lied about the Iraq war. Then they weren’t believed about Ukraine | Moustafa Bayoumi

26 février 2026 à 12:00

Will US intelligence learn its lessons from the Iraq war, and just how badly their legitimacy has been undermined?

Four years ago, on 24 February 2022, the Russian military began its full-scale invasion of Ukraine, having already occupied Crimea since 2014. Tensions between Ukraine’s government and western leaders on one side and the Kremlin on the other had been escalating for years, but war did not seem like a foregone conclusion, at least not to key European politicians and even to Volodymyr Zelenskyy, the Ukrainian president.

Zelenskyy hadn’t even packed an emergency suitcase, though talk of war was everywhere. All that changed at 4.50am that Thursday morning. Russian missiles rained down on the Ukrainian capital of Kyiv, and Russian troops invaded the eastern flank of the country on three different fronts. Zelenskyy and his family fled to an undisclosed location amid threats of Russian assassination squads. What has become the largest war on European soil since the second world war, what Putin has blandly called a “special military operation”, had begun.

Moustafa Bayoumi is the author of the award-winning books How Does It Feel To Be a Problem?: Being Young and Arab in America and This Muslim American Life: Dispatches from the War on Terror. He is Professor of English at Brooklyn College, City University of New York

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© Photograph: Pavel Bednyakov/EPA

© Photograph: Pavel Bednyakov/EPA

© Photograph: Pavel Bednyakov/EPA

Michel Maisonneuve: Jeneroux rewarded handsomely for his disloyalty

26 février 2026 à 12:00
Canadians woke up last Wednesday to the news that Matt Jeneroux, a Conservative MP, had decided to join the Liberal party. With the two other turncoats, Michael Ma and Chris d’Entremont, that makes three defections from Pierre Poilievre’s party since the federal election in April. Many pundits are predicting that the Liberals are going to achieve a majority through by-elections and possibly more defections. Fair-weather conservatives are continuing to wonder whether Poilievre is the right man to lead the party into the next election. Read More
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