With so much fascinating research going on in quantum science and technology, it’s hard to pick just a handful of highlights. Fun, but hard. Research on entanglement-based imaging and quantum error correction both appear in Physics World’s list of 2024’s top 10 breakthroughs, but beyond that, here are a few other achievements worth remembering as we head into 2025 – the International Year of Quantum Science and Technology.
In July, physicists at Germany’s Forschungszentrum Jülich and Korea’s IBS Center for Quantum Nanoscience (QNS) reported that they had fabricated a quantum sensor that can detect the electric and magnetic fields of individual atoms. The sensor consists of a molecule containing an unpaired electron (a molecular spin) that the physicists attached to the tip of a scanning-tunnelling microscope. They then used it to measure the magnetic and electric dipole fields emanating from a single iron atom and a silver dimer on a gold substrate.
Not to be outdone, an international team led by researchers at the University of Melbourne, Australia, announced in August that they had created a quantum sensor that detects magnetic fields in any direction. The new omnidirectional sensor is based on a recently-discovered carbon-based defect in a two-dimensional material, hexagonal boron nitride (hBN). This same material also contains a boron vacancy defect that enables the sensor to detect temperature changes, too.
One of the challenges with transmitting quantum information is that pretty much any medium you send it through – including high-spec fibre optic cables and even the Earth’s atmosphere – is at least somewhat good at absorbing photons and preventing them from reaching their intended destination.
In July, a team at the University of Chicago, the California Institute of Technology and Stanford University proposed a novel solution. A continent-scale network of vacuum-sealed tubes, they suggested, could transmit quantum information at rates as high as 1013 qubits per second. This would exceed currently-available quantum channels based on satellites or optical fibres by at least four orders of magnitude. Whether anyone will actually build such a network is, of course, yet to be determined – but you have to admire the ambition behind it.
Speaking of ambition, this year saw a remarkable flurry of ideas for using quantum devices and quantum principles to study gravity. One innovative proposal involves looking for the gravitational equivalent of the photoelectric effect in a system of resonant bars that have been cooled and tuned to vibrate when they absorb a graviton from an incoming gravitational wave. The idea is that absorbing a graviton would change the quantum state of the column, and this change of state would, in principle, be detectable.
Another quantum gravity proposal takes its inspiration from an even older experiment: the Cavendish torsion balance. The quantum version of this 18th-century classic would involve studying the correlations between two torsion pendula placed close together as they rotate back and forth like massive harmonic oscillators. If correlations appear that can’t be accounted for within a classical theory of gravity, this could imply that gravity is not, in fact, classical.
Perhaps the most exciting development in this space, though, is a new experimental technique for measuring the pull of gravity on a micron-scale particle. Objects of this size are just above the limit where quantum effects start to become apparent, and the Leiden and Southampton University researchers who performed the experiment have ideas for how to push their system further towards this exciting regime. Definitely one to keep an eye on.
It wouldn’t be quantum if it wasn’t at least little bit weird, so here’s a few head-scratchers for you to puzzle over.
This year, researchers in China substantially reduced the number of qubits required to verify an online shopping transaction. Physicists in Austria asked whether a classical computer can tell when a quantum computer is telling the truth. And in a development that’s sure to warm the hearts of quantum experimentalists the world over, physicists at the SLAC National Laboratory in the US suggested that if your qubits are going haywire and you don’t know why, maybe, just maybe, it’s because they’re being constantly bombarded with dark matter.
Using noisy qubits to detect dark matter? Now that really would be a breakthrough.
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From tumour-killing quantum dots to proton therapy firsts, this year has seen the traditional plethora of exciting advances in physics-based therapeutic and diagnostic imaging techniques, plus all manner of innovative bio-devices and biotechnologies for improving healthcare. Indeed, the Physics World Top 10 Breakthroughs for 2024 included a computational model designed to improve radiotherapy outcomes for patients with lung cancer by modelling the interaction of radiation with lung cells, as well as a method to make the skin of live mice temporarily transparent to enable optical imaging studies. Here are just a few more of the research highlights that caught our eye.
This year we reported on some important developments in the field of magnetic resonance imaging (MRI) technology, not least of which was the introduction of a 0.05 T whole-body MRI scanner that can produce diagnostic quality images. The ultralow-field scanner, invented at the University of Hong Kong’s BISP Lab, operates from a standard wall power outlet and does not require shielding cages. The simplified design makes it easier to operate and significantly lower in cost than current clinical MRI systems. As such, the BISP Lab researchers hope that their scanner could help close the global gap in MRI availability.
Moving from ultralow- to ultrahigh-field instrumentation, a team headed up by David Feinberg at UC Berkeley created an ultrahigh-resolution 7 T MRI scanner for imaging the human brain. The system can generate functional brain images with 10 times better spatial resolution than current 7 T scanners, revealing features as small as 0.35 mm, as well as offering higher spatial resolution in diffusion, physiological and structural MR imaging. The researchers plan to use their new NexGen 7 T scanner to study underlying changes in brain circuitry in degenerative diseases, schizophrenia and disorders such as autism.
Meanwhile, researchers at Massachusetts Institute of Technology and Harvard University developed a portable magnetic resonance-based sensor for imaging at the bedside. The low-field single-sided MR sensor is designed for point-of-care evaluation of skeletal muscle tissue, removing the need to transport patients to a centralized MRI facility. The portable sensor, which weighs just 11 kg, uses a permanent magnet array and surface RF coil to provide low operational power and minimal shielding requirements.
Alongside advances in diagnostic imaging, 2024 also saw a couple of firsts in the field of proton therapy. At the start of the year, OncoRay – the National Center for Radiation Research in Oncology in Dresden – launched the world’s first whole-body MRI-guided proton therapy system. The prototype device combines a horizontal proton beamline with a whole-body MRI scanner that rotates around the patient, a geometry that enables treatments both with patients lying down or in an upright position. Ultimately, the system could enable real-time MRI monitoring of patients during cancer treatments and significantly improve the targeting accuracy of proton therapy.
Also aiming to enhance proton therapy outcomes, a team at the PSI Center for Proton Therapy performed the first clinical implementation of an online daily adaptive proton therapy (DAPT) workflow. Online plan adaptation, where the patient remains on the couch throughout the replanning process, could help address uncertainties arising from anatomical changes during treatments. In five adults with tumours in rigid body regions treated using DAPT, the daily adapted plans provided target coverage to within 1.1% of the planned dose and, in over 90% of treatments, improved dose metrics to the targets and/or organs-at-risk. Importantly, the adaptive approach took just a few minutes longer than a non-adaptive treatment, remaining within the 30-min time slot allocated for a proton therapy session.
Last but certainly not least, this year saw several research teams demonstrate the use of tiny devices for cancer treatment. In a study conducted at the Institute for Bioengineering of Catalonia, for instance, researchers used self-propelling nanoparticles containing radioactive iodine to shrink bladder tumours.
Upon injection into the body, these “nanobots” search for and accumulate inside cancerous tissue, delivering radionuclide therapy directly to the target. Mice receiving a single dose of the nanobots experienced a 90% reduction in the size of bladder tumours compared with untreated animals.
At the Chinese Academy of Sciences’ Hefei Institutes of Physical Science, a team pioneered the use of metal-free graphene quantum dots for chemodynamic therapy. Studies in cancer cells and tumour-bearing mice showed that the quantum dots caused cell death and inhibition of tumour growth, respectively, with no off-target toxicity in the animals.
Finally, scientists at Huazhong University of Science and Technology developed novel magnetic coiling “microfibrebots” and used them to stem arterial bleeding in a rabbit – paving the way for a range of controllable and less invasive treatments for aneurysms and brain tumours.
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December might be dark and chilly here in the northern hemisphere, but it’s summer south of the equator – and for many people that means eating ice cream.
It turns out that the physics of ice cream is rather remarkable – as I discovered when I travelled to Canada’s University of Guelph to interview the food scientist Douglas Goff. He is a leading expert on the science of frozen desserts and in this podcast he talks about the unique material properties of ice cream, the analytical tools he uses to study it, and why ice cream goes off when it is left in the freezer for too long.
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