A research team headed up at Wayne State University School of Medicine in the US has developed a novel treatment for glioblastoma, based on exposure to low levels of radiofrequency electromagnetic fields (RF EMF). The researchers demonstrated that the new therapy slows the growth of glioblastoma cells in vitro and, for the first time, showed its feasibility and clinical impact in patients with brain tumours.
The study, led by Hugo Jimenez and reported in Oncotarget, uses a device developed by TheraBionic that delivers amplitude-modulated 27.12 MHz RF EMF throughout the entire body, via a spoon-shaped antenna placed on the tongue. Using tumour-specific modulation frequencies, the device has already received US FDA approval for treating patients with advanced hepatocellular carcinoma (HCC, a liver cancer), while its safety and effectiveness are currently being assessed in clinical trials in patients with pancreatic, colorectal and breast cancer.
In this latest work, the team investigated its use in glioblastoma, an aggressive and difficult to treat brain tumour.
To identify the particular frequencies needed to treat glioblastoma, the team used a non-invasive biofeedback method developed previously to study patients with various types of cancer. The process involves measuring variations in skin electrical resistance, pulse amplitude and blood pressure while individuals are exposed to low levels of amplitude-modulated frequencies. The approach can identify the frequencies, usually between 1 Hz and 100 kHz, specific to a single tumour type.
Jimenez and colleagues first examined the impact of glioblastoma-specific amplitude-modulated RF EMF (GBMF) on glioblastoma cells, exposing various cell lines to GBMF for 3 h per day at the exposure level used for patient treatments. After one week, GBMF decreased the proliferation of three glioblastoma cell lines (U251, BTCOE-4765 and BTCOE-4795) by 34.19%, 15.03% and 14.52%, respectively.
The team note that the level of this inhibitive effect (15–34%) is similar to that observed in HCC cell lines (19–47%) and breast cancer cell lines (10–20%) treated with tumour-specific frequencies. A fourth glioblastoma cell line (BTCOE-4536) was not inhibited by GBMF, for reasons currently unknown.
Next, the researchers examined the effect of GBMF on cancer stem cells, which are responsible for treatment resistance and cancer recurrence. The treatment decreased the tumour sphere-forming ability of U251 and BTCOE-4795 cells by 36.16% and 30.16%, respectively – also a comparable range to that seen in HCC and breast cancer cells.
Notably, these effects were only induced by frequencies associated with glioblastoma. Exposing glioblastoma cells to HCC-specific modulation frequencies had no measurable impact and was indistinguishable from sham exposure.
Looking into the underlying treatment mechanisms, the researchers hypothesized that – as seen in breast cancer and HCC – glioblastoma cell proliferation is mediated by T-type voltage-gated calcium channels (VGCC). In the presence of a VGCC blocker, GBMF did not inhibit cell proliferation, confirming that GBMF inhibition of cell proliferation depends on T-type VGCCs, in particular, a calcium channel known as CACNA1H.
The team also found that GBMF blocks the growth of glioblastoma cells by modulating the “Mitotic Roles of Polo-Like Kinase” signalling pathway, leading to disruption of the cells’ mitotic spindles, critical structures in cell replication.
Finally, the researchers used the TheraBionic device to treat two patients: a 38-year-old patient with recurrent glioblastoma and a 47-year-old patient with the rare brain tumour oligodendroglioma. The first patient showed signs of clinical and radiological benefit following treatment; the second exhibited stable disease and tolerated the treatment well.
“This is the first report showing feasibility and clinical activity in patients with brain tumour,” the authors write. “Similarly to what has been observed in patients with breast cancer and hepatocellular carcinoma, this report shows feasibility of this treatment approach in patients with malignant glioma and provides evidence of anticancer activity in one of them.”
The researchers add that a previous dosimetric analysis of this technique measured a whole-body specific absorption rate (SAR, the rate of energy absorbed by the body when exposed to RF EMF) of 1.35 mW/kg and a peak spatial SAR (over 1 g of tissue) of 146–352 mW/kg. These values are well within the safety limits set by the ICNIRP (whole-body SAR of 80 mW/kg; peak spatial SAR of 2000 mW/kg). Organ-specific values for grey matter, white matter and the midbrain also had mean SAR ranges well within the safety limits.
The team concludes that the results justify future preclinical and clinical studies of the TheraBionic device in this patient population. “We are currently in the process of designing clinical studies in patients with brain tumors,” Jimenez tells Physics World.
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As Europe prepares its next generation of Earth-Observation (EO) missions, a less visible but equally strategic challenge unfolds on the ground — how to manage the growing complexity of satellite […]
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Physicists at the Technical University of Denmark have demonstrated what they describe as a “strong and unconditional” quantum advantage in a photonic platform for the first time. Using entangled light, they were able to reduce the number of measurements required to characterize their system by a factor of 1011, with a correspondingly huge saving in time.
“We reduced the time it would take from 20 million years with a conventional scheme to 15 minutes using entanglement,” says Romain Brunel, who co-led the research together with colleagues Zheng-Hao Liu and Ulrik Lund Andersen.
Although the research, which is described in Science, is still at a preliminary stage, Brunel says it shows that major improvements are achievable with current photonic technologies. In his view, this makes it an important step towards practical quantum-based protocols for metrology and machine learning.
Quantum devices are hard to isolate from their environment and extremely sensitive to external perturbations. That makes it a challenge to learn about their behaviour.
To get around this problem, researchers have tried various “quantum learning” strategies that replace individual measurements with collective, algorithmic ones. These strategies have already been shown to reduce the number of measurements required to characterize certain quantum systems, such as superconducting electronic platforms containing tens of quantum bits (qubits), by as much as a factor of 105.
In the new study, Brunel, Liu, Andersen and colleagues obtained a quantum advantage in an alternative “continuous-variable” photonic platform. The researchers note that such platforms are far easier to scale up than superconducting qubits, which they say makes them a more natural architecture for quantum information processing. Indeed, photonic platforms have already been crucial to advances in boson sampling, quantum communication, computation and sensing.
The team’s experiment works with conventional, “imperfect” optical components and consists of a channel containing multiple light pulses that share the same pattern, or signature, of noise. The researchers began by performing a procedure known as quantum squeezing on two beams of light in their system. This caused the beams to become entangled – a quantum phenomenon that creates such a strong linkage that measuring the properties of one instantly affects the properties of the other.
The team then measured the properties of one of the beams (the “probe” beam) in an experiment known as a 100-mode bosonic displacement process. According to Brunel, one can imagine this experiment as being like tweaking the properties of 100 independent light modes, which are packets or beams of light. “A ‘bosonic displacement process’ means you slightly shift the amplitude and phase of each mode, like nudging each one’s brightness and timing,” he explains. “So, you then have 100 separate light modes, and each one is shifted in phase space according to a specific rule or pattern.”
By comparing the probe beam to the second (“reference”) beam in a single joint measurement, Brunel explains that he and his colleagues were able to cancel out much of the uncertainties in these measurements. This meant they could extract more information per trial than they could have by characterizing the probe beam alone. This information boost, in turn, allowed them to significantly reduce the number of measurements – in this case, by a factor of 1011.
While the DTU researchers acknowledge that they have not yet studied a practical, real-world system, they emphasize that their platform is capable of “doing something that no classical system will ever be able to do”, which is the definition of a quantum advantage. “Our next step will therefore be to study a more practical system in which we can demonstrate a quantum advantage,” Brunel tells Physics World.
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Malaysia and the Philippines have signed the Artemis Accords, which outline norms of behavior for space exploration.
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SAN FRANCISCO — Voyager Technologies announced the acquisition Oct. 27 of propulsion-system developer ExoTerra Resource. Terms of the deal were not disclosed. “We’re amplifying our collective mission capability with ExoTerra, accelerating delivery across defense and commercial markets,” Dylan Taylor, Voyager chairman and CEO, said in a statement. “As freedom of maneuver becomes central to space […]
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This episode of Physics World Stories features an interview with Jessica Esquivel and Emily Esquivel – the creative duo behind Queer Quest. The event created a shared space for 2SLGBTQIA+ Black and Brown people working in science, technology, engineering, arts and mathematics (STEAM).
Mental Health professionals also joined Queer Quest, which was officially recognised by UNESCO as part of the International Year of Quantum Science and Technology (IYQ). Over two days in Chicago this October, the event brought science, identity and wellbeing into powerful conversation.
Jessica Esquivel, a particle physicist and associate scientist at Fermilab, is part of the Muon g-2 experiment, pushing the limits of the Standard Model. Emily Esquivel is a licensed clinical professional counsellor. Together, they run Oyanova, an organization empowering Black and Brown communities through science and wellness.
Queer Quest blended keynote talks, with collective conversations, alongside meditation and other wellbeing activities. Panellists drew on quantum metaphors – such as entanglement – to explore identity, community and mental health.
In a wide-ranging conversation with podcast host Andrew Glester, Jessica and Emily speak about the inspiration for the event, and the personal challenges they have faced within academia. They speak about the importance of building resilience through community connections, especially given the social tensions in the US right now.
Hear more from Jessica Esquivel in her 2021 Physics World Stories appearance on the latest developments in muon science.
This article forms part of Physics World‘s contribution to the 2025 International Year of Quantum Science and Technology (IYQ), which aims to raise global awareness of quantum physics and its applications.
Stayed tuned to Physics World and our international partners throughout the year for more coverage of the IYQ.
Find out more on our quantum channel.
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Physicists have developed a novel imaging technique for detecting and characterizing objects hidden within opaque, highly scattering material. The researchers, from France and Austria, showed that their new mathematical approach, which utilizes the fact that hidden objects generate their own complex scattering pattern, or “fingerprint”, can work on biological tissue.
Viewing the inside of the human body is challenging due to the scattering nature of tissue. With ultrasound, when waves propagate through tissue they are reflected, bounce around and scatter chaotically, creating noise that obscures the signal from the object that the medical practitioner is trying to see. The further you delve into the body the more incoherent the image becomes.
There are techniques for overcoming these issues, but as scattering increases – in more complex media or as you push deeper through tissue – they struggle and unpicking the required signal becomes too complex.
The scientists behind the latest research, from the Institut Langevin in Paris, France and TU Wien in Vienna, Austria, say that rather than compensating for scattering, their technique instead relies on detecting signals from the hidden object in the disorder.
Objects buried in a material create their own complex scattering pattern, and the researchers found that if you know an object’s specific acoustic signal it’s possible to find it in the noise created by the surrounding environment.
“We cannot see the object, but the backscattered ultrasonic wave that hits the microphones of the measuring device still carries information about the fact that it has come into contact with the object we are looking for,” explains Stefan Rotter, a theoretical physicist at TU Wien.
Rotter and his colleagues examined how a series of objects scattered ultrasound waves in an interference-free environment. This created what they refer to as fingerprint matrices: measurements of the specific, characteristic way in which each object scattered the waves.
The team then developed a mathematical method that allowed them to calculate the position of each object when hidden in a scattering medium, based on its fingerprint matrix.
“From the correlations between the measured reflected wave and the unaltered fingerprint matrix, it is possible to deduce where the object is most likely to be located, even if the object is buried,” explains Rotter.
The team tested the technique in three different scenarios. The first experiment trialled the ultrasound imaging of metal spheres in a dense suspension of glass beads in water. Conventional ultrasound failed in this setup and the spheres were completely invisible, but with their novel fingerprint method the researchers were able to accurately detect them.
Next, to examine a medical application for the technique, the researchers embedded lesion markers often used to monitor breast tumours in a foam designed to mimic the ultrasound scattering of soft tissue. These markers can be challenging to detect due to scatterers randomly distributed in human tissue. With the fingerprint matrix, however, the researchers say that the markers were easy to locate.
Finally, the team successfully mapped muscle fibres in a human calf using the technique. They claim this could be useful for diagnosing and monitoring neuromuscular diseases.
According to Rotter and his colleagues, their fingerprint matrix method is a versatile and universal technique that could be applied beyond ultrasound to all fields of wave physics. They highlight radar and sonar as examples of sensing techniques where target identification and detection in noisy environments are long-standing challenges.
“The concept of the fingerprint matrix is very generally applicable – not only for ultrasound, but also for detection with light,” Rotter says. “It opens up important new possibilities in all areas of science where a reflection matrix can be measured.”
The researchers report their findings in Nature Physics.
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Networking specialist MTN has launched a service that enables SpaceX’s Starlink LEO satellites to operate as part of a privately secured communications system, giving businesses a way to link remote sites without using the public internet.
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When America embarked on the journey to build the Arsenal of Democracy in World War II, President Roosevelt had a simple instruction: “speed, speed, speed.” His emphasis on speed spurred on the production of lethal, mass-producible American warplanes that enabled the United States to win WWII. Some 80 years later, the urgency for speed is […]
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Iridium Communications plans to release a tiny chip next year to protect devices relying on navigation satellites from jamming and spoofing, reinforcing one of the L-band operator’s core strengths as SpaceX’s Starlink encroaches on other parts of its business.
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China added to its Earth observation fleet late Saturday, sending a second Gaofen-14 mapping satellite into sun-synchronous orbit.
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Obviously, I write: I wouldn’t be a very good science writer if I couldn’t. So communication skills are vital. Recently, for example, Qruise launched a new magnetic-resonance product for which I had to write a press release, create a new webpage and do social-media posts. That meant co-ordinating with lots of different people, finding out the key features to advertise, identifying the claims we wanted to make – and if we have the data to back those claims up. I’m not an expert in quantum computing or magnetic-resonance imagining or even marketing so I have to pick things up fast and then translate technically complex ideas from physics and software into simple messages for a broader audience. Thankfully, my colleagues are always happy to help. Science writing is a difficult task but I think I’m getting better at it.
I love the variety and the fact that I’m doing so many different things all the time. If there’s a day I feel I want something a little bit lighter, I can do some social media or the website, which is more creative. On the other hand, if I feel I could really focus in detail on something then I can write some documentation that is a little bit more technical. I also love the flexibility of remote working, but I do miss going to the office and socialising with my colleagues on a regular basis. You can’t get to know someone as well online, it’s nicer to have time with them in person.
That’s a hard one. It would be easy to say I wish I’d known earlier that I could combine science and writing and make a career out of that. On the other hand, if I’d known that, I might not have done my PhD – and if I’d gone into writing straight after my undergraduate degree, I perhaps wouldn’t be where I am now. My point is, it’s okay not to have a clear plan in life. As children, we’re always asked what we want to be – in my case, my dream from about the age of four was to be a vet. But then I did some work experience in a veterinary practice and I realized I’m really squeamish. It was only when I was 15 or 16 that I discovered I wanted to do physics because I liked it and was good at it. So just follow the things you love. You might end up doing something you never even thought was an option.
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