Labour will need a different leader if it pursues a policy of rejoining the EU customs union or single market

Trial results mark boost to US pharmaceutical company’s booming obesity business

Cheaper generics will be allowed on to market a year earlier to curb costs

Beijing and several European countries hold up deal to exempt US multinationals from OECD tax regime

Neobank wants to put its £12bn of deposits to more profitable use

US database company’s earnings published on Wednesday fell short of forecasts amid concerns over AI boom

Known as the Donbas, the region has become the fulcrum of fraught US-led diplomacy to end Russia’s full-scale invasion

Nik Storonsky is demanding and disruptive but he is building a world-leading bank

How the energy giants tried to transform their businesses — but ended up dramatically scaling back those plans and writing off billions of dollars

Companies and industries divided over bloc’s ‘Made in Europe’ plans

Modelling by independent body Neso forecasts sharp fall in expenditure from 10% of GDP as shift to renewables continues

Oil price jumps as Washington piles pressure on Nicolás Maduro’s regime

US central bank to purchase short-term Treasuries just weeks after it stopped shrinking its balance sheet

María Corina Machado emerges after more than a year in hiding but misses peace prize ceremony

Larry Ellison’s company raises its capital expenditure forecast as it doubles down on AI infrastructure bet

Three top US central bankers object to move in biggest revolt since 2019

Discussions on reconstruction come as Donald Trump seeks end to Russian invasion

Row over cap on unfair dismissal payouts in House of Lords threatens to delay delivery of manifesto pledge

Backing from Saudi Arabia, UAE and Qatar represents latest push into prized international media assets

Keir Starmer has become increasingly frustrated by House of Lords attempts to curb government bills

British prime minister delivers his strongest rejection yet of calls to rejoin bloc

Three members of central bank’s board oppose decision in biggest dissent since 2019

UK healthy fast-food chain bought back by John Vincent last month has struggled to recover from Covid

Defence secretary John Healey says Britain is ‘all-in’ on trilateral submarine and technology pact