A new heat engine driven by the temperature difference between Earth’s surface and outer space has been developed by Tristan Deppe and Jeremy Munday at the University of California Davis. In an outdoor trial, the duo showed how their engine could offer a reliable source of renewable energy at night.

While solar cells do a great job of converting the Sun’s energy into electricity, they have one major drawback, as Munday explains: “Lack of power generation at night means that we either need storage, which is expensive, or other forms of energy, which often come from fossil fuel sources.”

One solution is to exploit the fact that the Earth’s surface absorbs heat from the Sun during the day and then radiates some of that energy into space at night. While space has a temperature of around −270° C, the average temperature of Earth’s surface is a balmy 15° C. Together, these two heat reservoirs provide the essential ingredients of a heat engine, which is a device that extracts mechanical work as thermal energy flows from a heat source to a heat sink.

Coupling to space

“At first glance, these two entities appear too far apart to be connected through an engine. However, by radiatively coupling one side of the engine to space, we can achieve the needed temperature difference to drive the engine,” Munday explains.

For the concept to work, the engine must radiate the energy it extracts from the Earth within the atmospheric transparency window. This is a narrow band of infrared wavelengths that pass directly into outer space without being absorbed by the atmosphere.

To demonstrate this concept, Deppe and Munday created a Stirling engine, which operates through the cyclical expansion and contraction of an enclosed gas as it moves between hot and cold ends. In their setup, the ends were aligned vertically, with a pair of plates connecting each end to the corresponding heat reservoir.

For the hot end, an aluminium mount was pressed into soil, transferring the Earth’s ambient heat to the engine’s bottom plate. At the cold end, the researchers attached a black-coated plate that emitted an upward stream of infrared radiation within the transparency window.

Outdoor experiments

In a series of outdoor experiments performed throughout the year, this setup maintained a temperature difference greater than 10° C between the two plates during most months. This was enough to extract more than 400 mW per square metre of mechanical power throughout the night.

“We were able to generate enough power to run a mechanical fan, which could be used for air circulation in greenhouses or residential buildings,” Munday describes. “We also configured the device to produce both mechanical and electrical power simultaneously, which adds to the flexibility of its operation.”

With this promising early demonstration, the researchers now predict that future improvements could enable the system to extract as much as 6 W per square metre under the same conditions. If rolled out commercially, the heat engine could help reduce the reliance of solar power on night-time energy storage – potentially opening a new route to cutting carbon emissions.

The research has described in Science Advances.

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A new microscale version of the flumes that are commonly used to reproduce wave behaviour in the laboratory will make it far easier to study nonlinear hydrodynamics. The device consists of a layer of superfluid helium just a few atoms thick on a silicon chip, and its developers at the University of Queensland, Australia, say it could help us better understand phenomena ranging from oceans and hurricanes to weather and climate.

“The physics of nonlinear hydrodynamics is extremely hard to model because of instabilities that ultimately grow into turbulence,” explains study leader Warwick Bowen of Queensland’s Quantum Optics Laboratory. “It is also very hard to study in experiments since these often require hundreds-of-metre-long wave flumes.”

While such flumes are good for studying shallow-water dynamics like tsunamis and rogue waves, Bowen notes that they struggle to access many of the complex wave behaviours, such as turbulence, found in nature.

Amplifying the nonlinearities in complex behaviours

The team say that the geometrical structure of the new wave-on-a-chip device can be designed at will using lithographic techniques and built in a matter of days. Superfluid helium placed on its surface can then be controlled optomechanically. Thanks to these innovations, the researchers were able to experimentally measure nonlinear hydrodynamics millions of times faster than would be possible using traditional flumes. They could also “amplify” the nonlinearities of complex behaviours, making them orders of magnitude stronger than is possible in even the largest wave flumes.

“This promises to change the way we do nonlinear hydrodynamics, with the potential to discover new equations that better explain the complex physics behind it,” Bowen says. “Such a technique could be used widely to improve our ability to predict both natural and engineered hydrodynamic behaviours.”

So far, the team has measured several effects, including wave steepening, shock fronts and solitary wave fission thanks to the chip. While these nonlinear behaviours had been predicted in superfluids, they had never been directly observed there until now.

Waves can be generated in a very shallow depth

The Quantum Optics Laboratory researchers have been studying superfluid helium for over a decade. A key feature of this quantum liquid is that it flows without resistance, similar to the way electrons move without resistance in a superconductor. “We realized that this behaviour could be exploited in experimental studies of nonlinear hydrodynamics because it allows waves to be generated in a very shallow depth – even down to just a few atoms deep,” Bowen explains.

In conventional fluids, Bowen continues, resistance to motion becomes hugely important at small scales, and ultimately limits the nonlinear strengths accessible in traditional flume-based testing rigs. “Moving from the tens-of-centimetre depths of these flumes to tens-of-nanometres, we realized that superfluid helium could allow us to achieve many orders of magnitude stronger nonlinearities – comparable to the largest flows in the ocean – while also greatly increasing measurement speeds. It was this potential that attracted us to the project.”

The experiments were far from simple, however. To do them, the researchers needed to cryogenically cool the system to near absolute zero temperatures. They also needed to fabricate exceptionally thin superfluid helium films that interact very weakly with light, as well as optical devices with structures smaller than a micron. Combining all these components required what Bowen describes as “something of a hero experiment”, with important contributions coming from the team’s co-leader, Christopher Baker, and Walter Wasserman, who was then a PhD student in the group. The wave dynamics themselves, Bowen adds, were “exceptionally complex” and were analysed by Matthew Reeves, the first author of a Science paper describing the device.

As well as the applications areas mentioned earlier, the team say the new work, which is supported by the US Defense Advanced Research Project Agency’s APAQuS Program, could also advance our understanding of strongly-interacting quantum structures that are difficult to model theoretically. “Superfluid helium is a classic example of such a system,” explains Bowen, “and our measurements represent the most precise measurements of wave physics in these. Other applications may be found in quantum technologies, where the flow of superfluid helium could – somewhat speculatively – replace superconducting electron flow in future quantum computing architectures.”

The researchers now plan to use the device and machine learning techniques to search for new hydrodynamics equations.

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An effect first observed decades ago by Nobel laureate Arthur Ashkin has been used to fine tune the electrical charge on objects held in optical tweezers. Developed by an international team led by Scott Waitukaitis of the Institute of Science and Technology Austria, the new technique could improve our understanding of aerosols and clouds.

Optical tweezers use focused laser beams to trap and manipulate small objects about 100 nm to 1 micron in size. Their precision and versatility have made them a staple across fields from quantum optics to biochemistry.

Ashkin shared the 2018 Nobel prize for inventing optical tweezers and in the 1970s he noticed that trapped objects can be electrically charged by the laser light. “However, his paper didn’t get much attention, and the observation has essentially gone ignored,” explains Waitukaitis.

Waitukaitis’ team rediscovered the effect while using optical tweezers to study how charges build up in the ice crystals accumulating inside clouds. In their experiment, micron-sized silica spheres stood in for the ice, but Ashkin’s charging effect got in their way.

Bummed out

“Our goal has always been to study charged particles in air in the context of atmospheric physics – in lightning initiation or aerosols, for example,” Waitukaitis recalls. “We never intended for the laser to charge the particle, and at first we were a bit bummed out that it did so.”

Their next thought was that they had discovered a new and potentially useful phenomenon. “Out of due diligence we of course did a deep dive into the literature to be sure that no one had seen it, and that’s when we found the old paper from Ashkin, “ says Waitukaitis.

In 1976, Ashkin described how optically trapped objects become charged through a nonlinear process whereby electrons absorb two photons simultaneously. These electrons can acquire enough energy to escape the object, leaving it with a positive charge.

Yet beyond this insight, Ashkin “wasn’t able to make much sense of the effect,” Waitukaitis explains. “I have the feeling he found it an interesting curiosity and then moved on.”

Shaking and scattering

To study the effect in more detail, the team modified their optical tweezers setup so its two copper lens holders doubled as electrodes, allowing them to apply an electric field along the axis of the confining, opposite-facing laser beams. If the silica sphere became charged, this field would cause it to shake, scattering a portion of the laser light back towards each lens.

The researchers picked off this portion of the scattered light using a beam splitter, then diverted it to a photodiode, allowing them to track the sphere’s position. Finally, they converted the measured amplitude of the shaking particle into a real-time charge measurement. This allowed them to track the relationship between the sphere’s charge and the laser’s tuneable intensity.

Their measurements confirmed Ashkin’s 1976 hypothesis that electrons on optically-trapped objects undergo two-photon absorption, allowing them to escape. Waitukaitis and colleagues improved on this model and showed how the charge on a trapped object can be controlled precisely by simply adjusting the laser’s intensity.

As for the team’s original research goal, the effect has actually been very useful for studying the behaviour of charged aerosols.

“We can get [an object] so charged that it shoots off little ‘microdischarges’ from its surface due to breakdown of the air around it, involving just a few or tens of electron charges at a time,” Waitukaitis says. “This is going to be really cool for studying electrostatic phenomena in the context of particles in the atmosphere.“

The study is described in Physical Review Letters.

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Earlier this autumn I had the pleasure of visiting the Perimeter Institute for Theoretical Physics in Waterloo Canada – where I interviewed four physicists about their research. This is the second of those conversations to appear on the podcast – and it is with Bianca Dittrich, whose research focuses on quantum gravity.

Albert Einstein’s general theory of relativity does a great job at explaining gravity but it is thought to be incomplete because it is incompatible with quantum mechanics. This is an important shortcoming because quantum mechanics is widely considered to be one of science’s most successful theories.

Developing a theory of quantum gravity is a crucial goal in physics, but it is proving to be extremely difficult. In this episode, Dittrich explains some of the challenges and talks about ways forward – including her current research on spin foams. We also chat about the intersection of quantum gravity and condensed matter physics; and the difficulties of testing theories against observational data.

• The first interview in this series from the PI was with Javier Toledo-Marín: “Quantum computing and AI join forces for particle physics”

The post Quantum gravity: we explore spin foams and other potential solutions to this enduring challenge appeared first on Physics World.

En sortant l'iPhone Air, Apple voulait démontrer son savoir faire dans un volume inédit pour un smartphone de cette taille.
Il semble toutefois que les ventes se soient avérées bien en deçà des attentes (les autres iPhone se vendent très bien). La production de ce modèle aurait déjà été arrêtée sans prévisions de la relancer, Foxconn ayant démantelé les chaînes de production et les sous-traitant cessé de produire les composants.
Cet échec aurait conduit les concurrents d'Apple chinois qui voulaient suivre cet exemple à cesser leurs efforts pour produire des appareils très fins.

Tout n'est toutefois pas terminé car Apple n'a pas abandonné l'idée d'en sortir une seconde version en 2026. Elle devrait tirer partie de ce qui n'a pas été apprécié dans le premier modèle, à commencer par la présence d'un unique capteur photo.

Nous pensons qu'une des choses qui a participé à cet échec est liée à la politique commerciale d'Apple. Lancer en même temps que le l'iPhone Air une batterie additionnelle lui enlevant tout intérêt n'a fait que montrer que son autonomie était trop faible pour les standards actuels.
Rendez-vous courant 2026 pour voir si la seconde mouture attirera plus de monde.

Qubits – the building blocks of quantum computers – are plagued with a seemingly unsurmountable dilemma. If they’re fast, they aren’t robust. And if they’re robust, they aren’t fast. Both qualities are important, because all potentially useful quantum algorithms rely on being able to perform many manipulations on a qubit before its state decays. But whereas faster qubits are typically realized by strongly coupling them to the external environment, enabling them to interact more strongly with the driving field, robust qubits with long coherence times are typically achieved by isolating them from their environment.

These seemingly contradictory requirements made simultaneously fast and robust qubits an unsolved challenge – until now. In an article published in Nature Communications, a team of physicists led by Dominik Zumbühl from the University of Basel, Switzerland show that it is, in fact, possible to increase both the coherence time and operational speed of a qubit, demonstrating a pathway out of this long-standing impasse.

The magic ingredient

The key ingredient driving this discovery is something called the direct Rashba spin-orbit interaction. The best-known example of spin-orbit interaction comes from atomic physics. Consider a hydrogen atom, in which a single electron revolves around a single proton in the nucleus. During this orbital motion, the electron interacts with the static electric field generated by the positively charged nucleus. The electron in turn experiences an effective magnetic field that couples to the electron’s intrinsic magnetic moment, or spin. This coupling of the electron’s orbital motion to its spin is called spin-orbit (SO) interaction.

Aided by collaborators at the University of Oxford, UK and TU Eindhoven in the Netherlands, Zumbühl and colleagues chose to replace this simple SO interaction with a far more complex landscape of electrostatic potential generated by a 10-nanometer-thick germanium wire coated with a thin silicon shell. By removing a single electron from this wire, they create states known as holes that can be used as qubits, with quantum information being encoded in the hole’s spin.

Importantly, the underlying crystal structure of the silicon-coated germanium wire constrains these holes to discrete energy levels called bands. “If you were to mathematically model a low-level hole residing in one of these bands using perturbation theory – a commonly applied method in which more remote bands are treated as corrections to the ground state – you would find a term that looks structurally similar to the spin–orbit interaction known from atomic physics,” explains Miguel Carballido, who conducted the work during his PhD at Basel, and is now a senior research associate at the University of New South Wales’ School of Electrical Engineering and Telecommunications in Sydney, Australia.

By encoding the quantum states in these energy levels, the spin-orbit interaction can be used to drive the hole-qubit between its two spin states. What makes this interaction special is that it can be tuned using an external electric field. Thus, by applying a stronger electric field, the interaction can be strengthened – resulting in faster qubit manipulation.

Reaching a plateau

This ability to make a qubit faster by tuning an external parameter isn’t new. The difference is that whereas in other approaches, a stronger interaction also means higher sensitivity to fluctuations in the driving field, the Basel researchers found a way around this problem. As they increase the electric field, the spin-orbit interaction increases up to a certain point. Beyond this point, any further increase in the electric field will cause the hole to remain stuck within a low energy band. This restricts the hole’s ability to interact with other bands to change its spin, causing the SO interaction strength to drop.

By tuning the electric field to this peak, they can therefore operate in a “plateau” region where the SO interaction is the strongest, but the sensitivity to noise is the lowest. This leads to high coherence times (see figure), meaning that the qubit remains in the desired quantum state for longer. By reaching this plateau, where the qubit is both fast and robust, the researchers demonstrate the ability to operate their device in the “compromise-free” regime.

So, is quantum computing now a solved problem? The researchers’ answer is “not yet”, as there are still many challenges to overcome. “A lot of the heavy lifting is being done by the quasi 1D system provided by the nanowire,” remarks Carballido, “but this also limits scalability.” He also notes that the success of the experiment depends on being able to fabricate each qubit device very precisely, and doing this reproducibly remains a challenge.

The post Can fast qubits also be robust? appeared first on Physics World.

On se souvient des décevants Snapdragon X [1] de 2024, que Qualcomm voulait comparer au M2 de base. Même pas au M2 Pro ou M2 Max. Puis au M3 au fur et à mesure que sa date de sortie était repoussée.

Qualcomm comparait son haut-de-gamme avec l'entrée-de-gamme Apple : ça dit tout sur le manque de performances. La GPU du Snapdragon X [1] était aussi décevante, ils ont convaincu les youtubeurs de la tester sur des jeux en 720p, pas en 1080p...

Voilà la seconde génération, Snapdragon X2, avec laquelle Qualcomm ne recommence pas ce genre de comparaison hautement fumeuse.

J'ai des réserves sur la micro-architecture des cœurs CPU, mais cela est largement compensé par des fréquences en hausse (5,0 GHz), et par la pléthore de cœurs, 12 rapides et 6 économiques. 12 cœurs en entrée-de-gamme et 18 cœurs dès le milieu-de-gamme !

La GPU en revanche ne présage rien de vraiment bon, faute de bande-passante mémoire, ça n'est pas la force de Qualcomm, et au mieux elle peut viser un M4 Pro.
Du progrès quand-même, ce coup-ci, au moins en haut-de-gamme, on pourra enfin jouer en 1080p...

Mais, on pourrait être surpris coté CPU, quoique le M4 Pro 14 cœurs soit bien velu !
Voilà le PDF de présentation des Qualcomm Snapdragon X2 (en Anglais)

En ce moment, profitez du Black Friday : soutenez MacBidouille et partagez vos trouvailles

In the early universe, moments after the Big Bang and cosmic inflation, clusters of exotic, massive particles could have collapsed to form bizarre objects called cannibal stars and boson stars. In turn, these could have then collapsed to form primordial black holes – all before the first elements were able to form.

This curious chain of events is predicted by a new model proposed by a trio of scientists at SISSA, the International School for Advanced Studies in Trieste, Italy.

Their proposal involves a hypothetical moment in the early universe called the early matter-dominated (EMD) epoch. This would have lasted only a few seconds after the Big Bang, but could have been dominated by exotic particles, such as the massive, supersymmetric particles predicted by string theory.

“There are no observations that hint at the existence of an EMD epoch – yet!” says SISSA’s Pranjal Ralegankar. “But many cosmologists are hoping that an EMD phase occurred because it is quite natural in many models.”

Some models of the early universe predict the formation of primordial black holes from quantum fluctuations in the inflationary field. Now, Ralegankar and his colleagues, Daniele Perri and Takeshi Kobayashi propose a new and more natural pathway for forming primordial holes via an EMD epoch.

They postulate that in the first second of existence when the universe was small and incredibly hot, exotic massive particles emerged and clustered in dense haloes. The SISSA physicists propose that the haloes then collapsed into hypothetical objects called cannibal stars and boson stars.

Cannibal stars are powered by particles annihilating each other, which would have allowed the objects to resist further gravitational collapse for a few seconds. However, they would not have produced light like normal stars.

“The particles in a cannibal star can only talk to each other, which is why they are forced to annihilate each other to counter the immense pressure from gravity,” Ralegankar tells Physics World. “They are immensely hot, simply because the particles that we consider are so massive. The temperature of our cannibal stars can range from a few GeV to on the order of 10¹⁰ GeV. For comparison, the Sun is on the order of keV.”

Boson stars, meanwhile, would be made from pure a Bose–Einstein condensate, which is a state of matter whereby the individual particles quantum mechanically act as one.

Both the cannibal stars and boson stars would exist within larger haloes that would quickly collapse to form primordial black holes with masses about the same as asteroids (about 10¹⁴–10¹⁹ kg). All of this could have taken place just 10 s after the Big Bang.

Dark matter possibility

Ralegankar, Perri and Kobayashi point out that the total mass of primordial black holes that their model produces matches the amount of dark matter in the universe.

“Current observations rule out black holes to be dark matter, except in the asteroid-mass range,” says Ralegankar. “We showed that our models can produce black holes in that mass range.”

Richard Massey, who is a dark-matter researcher at Durham University in the UK, agrees that microlensing observations by projects such as the Optical Gravitational Lensing Experiment (OGLE) have ruled out a population of black holes with planetary masses, but not asteroid masses. However, Massey is doubtful that these black holes could make up dark matter.

“It would be pretty contrived for them to make up a large fraction of what we call dark matter,” he says. “It’s possible that dark matter could be these primordial black holes, but they’d need to have been created with the same mass no matter where they were and whatever environment they were in, and that mass would have to be tuned to evade current experimental evidence.”

In the coming years, upgrades to OGLE and the launch of NASA’s Roman Space Telescope should finally provide sensitivity to microlensing events produced by objects in the asteroid mass range, allowing researchers to settle the matter.

It is also possible that cannibal and boson stars exist today, produced by collapsing haloes of dark matter. But unlike those proposed for the early universe, modern cannibal and boson stars would be stable and long-lasting.

“Much work has already been done for boson stars from dark matter, and we are simply suggesting that future studies should also think about the possibility of cannibal stars from dark matter,” explains Ralegankar. “Gravitational lensing would be one way to search for them, and depending on models, maybe also gamma rays from dark-matter annihilation.”

The research is described in Physical Review D.

The post Did cannibal stars and boson stars populate the early universe? appeared first on Physics World.

The deliberate targeting of scientists in recent years has become one of the most disturbing, and overlooked, developments in modern conflict. In particular, Iranian physicists and engineers have been singled out for almost two decades, with sometimes fatal consequences. In 2007 Ardeshir Hosseinpour, a nuclear physicist at Shiraz University, died in mysterious circumstances that were widely attributed to poisoning or radioactive exposure.

Over the following years, at least five more Iranian researchers have been killed. They include particle physicist Masoud Ali-Mohammadi, who was Iran’s representative at the Synchrotron-light for Experimental Science and Applications in the Middle East project. Known as SESAME, it is the only scientific project in the Middle East where Iran and Israel collaborate.

Others to have died include nuclear engineer Majid Shahriari, another Iranian representative at SESAME, and nuclear physicist Mohsen Fakhrizadeh, who were both killed by bombing or gunfire in Tehran. These attacks were never formally acknowledged, nor were they condemned by international scientific institutions. The message, however, was implicit: scientists in politically sensitive fields could be treated as strategic targets, even far from battlefields.

What began as covert killings of individual researchers has now escalated, dangerously, into open military strikes on academic communities. Israeli airstrikes on residential areas in Tehran and Isfahan during the 12-day conflict between the two countries in June led to at least 14 Iranian scientists and engineers and members of their family being killed. The scientists worked in areas such as materials science, aerospace engineering and laser physics. I believe this shift, from covert assassinations to mass casualties, crossed a line. It treats scientists as enemy combatants simply because of their expertise.

The assassinations of scientists are not just isolated tragedies; they are a direct assault on the global commons of knowledge, corroding both international law and international science. Unless the world responds, I believe the precedent being set will endanger scientists everywhere and undermine the principle that knowledge belongs to humanity, not the battlefield.

Drawing a red line

International humanitarian law is clear: civilians, including academics, must be protected. Targeting scientists based solely on their professional expertise undermines the Geneva Convention and erodes the civilian–military distinction at the heart of international law.

Iran, whatever its politics, remains a member of the Nuclear Non-Proliferation Treaty and the International Atomic Energy Agency. Its scientists are entitled under international law to conduct peaceful research in medicine, energy and industry. Their work is no more inherently criminal than research that other countries carry out in artificial intelligence (AI), quantum technology or genetics.

If we normalize the preemptive assassination of scientists, what stops global rivals from targeting, say, AI researchers in Silicon Valley, quantum physicists in Beijing or geneticists in Berlin? Once knowledge itself becomes a liability, no researcher is safe. Equally troubling is the silence of the international scientific community with organizations such as the UN, UNESCO and the European Research Council as well as leading national academies having not condemned these killings, past or present.

Silence is not neutral. It legitimizes the treatment of scientists as military assets. It discourages international collaboration in sensitive but essential research and it creates fear among younger researchers, who may abandon high-impact fields to avoid risk. Science is built on openness and exchange, and when researchers are murdered for their expertise, the very idea of science as a shared human enterprise is undermined.

The assassinations are not solely Iran’s loss. The scientists killed were part of a global community; collaborators and colleagues in the pursuit of knowledge. Their deaths should alarm every nation and every institution that depends on research to confront global challenges, from climate change to pandemics.

I believe that international scientific organizations should act. At a minimum, they should publicly condemn the assassination of scientists and their families; support independent investigations under international law; as well as advocate for explicit protections for scientists and academic facilities in conflict zones.

Importantly, voices within Israel’s own scientific community can play a critical role too. Israeli academics, deeply committed to collaboration and academic freedom, understand the costs of blurring the boundary between science and war. Solidarity cannot be selective.

Recent events are a test case for the future of global science. If the international community tolerates the targeting of scientists, it sets a dangerous precedent that others will follow. What appears today as a regional assault on scientists from the Global South could tomorrow endanger researchers in China, Europe, Russia or the US.

Science without borders can only exist if scientists are recognized and protected as civilians without borders. That principle is now under direct threat and the world must draw a red line – killing scientists for their expertise is unacceptable. To ignore these attacks is to invite a future in which knowledge itself becomes a weapon, and the people who create it expendable. That is a world no-one should accept.

The post Academic assassinations are a threat to global science appeared first on Physics World.

DNA is a fascinating macromolecule that guides protein production and enables cell replication. It has also found applications in nanoscience and materials design.

Colloidal crystals are ordered structures made from tiny particles suspended in fluid that can bond to other particles and add functionalisation to materials. By controlling colloidal particles, we can build advanced nanomaterials using a bottom-up approach. There are several ways to control colloidal particle design, ranging from experimental conditions such as pH and temperature to external controls like light and magnetic fields.

An exciting approach is to use DNA-mediated processes. DNA binds to colloidal surfaces and regulates how the colloids organize, providing molecular-level control. These connections are reversible and can be broken using standard experimental conditions (e.g., temperature), allowing for dynamic and adaptable systems. One important motivation is their good biocompatibility, which has enabled applications in biomedicine such as drug delivery, biosensing, and immunotherapy.

Programmable Atom Equivalents (PAEs) are large colloidal particles whose surfaces are functionalized with single-stranded DNA, while separate, much smaller DNA-coated linkers, called Electron Equivalents (EEs), roam in solution and mediate bonds between PAEs. In typical PAE-EE systems, the EEs carry multiple identical DNA ends that can all bind the same type of PAE, which limits the complexity of the assemblies and makes it harder to program highly specific connections between different PAE types.

In this study, the researchers investigate how EEs with arbitrary valency, carrying many DNA arms, regulate interactions in a binary mixture of two types of PAEs. Each EE has multiple single-stranded DNA ends of two different types, each complementary to the DNA on one of the PAE species. The team develops a statistical mechanical model to predict how EEs distribute between the PAEs and to calculate the effective interaction, a measure of how strongly the PAEs attract each other, which in turn controls the structures that can form.

Using this model, they inform Monte Carlo simulations to predict system behaviour under different conditions. The model shows quantitative agreement with simulation results and reveals an anomalous dependence of PAE-PAE interactions on EE valency, with interactions converging at high valency. Importantly, the researchers identify an optimal valency that maximizes selectivity between targeted and non-targeted binding pairs. This groundbreaking research provides design principles for programmable self-assembly and offers a framework that can be integrated into DNA nanoscience.

Do you want to learn more about this topic?

Assembly of colloidal particles in solution by Kun Zhao and Thomas G Mason (2018)

The post DNA as a molecular architect appeared first on Physics World.

Proteins are made up of a sequence of building blocks called amino acids. Understanding these sequences is crucial for studying how proteins work, how they interact with other molecules, and how changes (mutations) can lead to diseases.

These mutations happen over vastly different time periods and are not completely random but strongly correlated, both in space (distinct sites along the sequences) and in time (subsequent mutations of the same site).

It turns out that these correlations are very reminiscent of disordered physical systems, notably glasses, emulsions, and foams.

A team of researchers from Italy and France have now used this similarity to build a new statistical model to simulate protein evolution.  They went on to study the role of different factors causing these mutations.

They found that the initial (ancestral) protein sequence has a significant influence on the evolution process, especially in the short term. This means that information from the ancestral sequence can be traced back over a certain period and is not completely lost.

The strength of interactions between different amino acids within the protein affects how long this information persists.

Although ultimately the team did find differences between the evolution of physical systems and that of protein sequences, this kind of insight would not have been possible without using the language of statistical physics, i.e. space-time correlations.

The researchers expect that their results will soon be tested in the lab thanks to upcoming advances in experimental techniques.

The post The link between protein evolution and statistical physics appeared first on Physics World.