Early diagnosis of primary central nervous system lymphoma (PCNSL) remains challenging because brain biopsies are invasive and imaging often lacks molecular specificity. A team led by researchers at Shenzhen University has now developed a minimally invasive fibre-optic plasmonic sensor capable of detecting PCNSL-associated microRNAs in the eye’s aqueous humor with attomolar sensitivity.

At the heart of the approach is a black phosphorus (BP)–engineered surface plasmon resonance (SPR) interface. An ultrathin BP layer is deposited on a gold-coated fiber tip. Because of the work-function difference between BP and gold, electrons transfer from BP into the Au film, creating a strongly enhanced local electric field at the metal–semiconductor interface. This BP–Au charge-transfer nano-interface amplifies refractive-index changes at the surface far more efficiently than conventional metal-only SPR chips, enabling the detection of molecular interactions that would otherwise be too subtle to resolve and pushing the limit of detection down to 21 attomolar without nucleic-acid amplification. The BP layer also provides a high-area, biocompatible surface for immobilizing RNA reporters.

To achieve sequence specificity, the researchers integrated CRISPR-Cas13a, an RNA-guided nuclease that becomes catalytically active only when its target sequence is perfectly matched to a designed CRISPR RNA (crRNA). When the target microRNA (miR-21) is present, activated Cas13a cleaves RNA reporters attached to the BP-modified fiber surface, releasing gold nanoparticles and reducing the local refractive index. The resulting optical shift is read out in real time through the SPR response of the BP-enhanced fiber probe, providing single-nucleotide-resolved detection directly on the plasmonic interface.

With this combined strategy, the sensor achieved a limit of detection of 21 attomolar in buffer and successfully distinguished single-base-mismatched microRNAs. In tests on aqueous-humor samples from patients with PCNSL, the CRISPR-BP-FOSPR assay produced results that closely matched clinical qPCR data, despite operating without any amplification steps.

Because aqueous-humor aspiration is a minimally invasive ophthalmic procedure, this BP-driven plasmonic platform may offer a practical route for early PCNSL screening, longitudinal monitoring, and potentially the diagnosis of other neurological diseases reflected in eye-fluid biomarkers. More broadly, the work showcases how black-phosphorus-based charge-transfer interfaces can be used to engineer next-generation, fibre-integrated biosensors that combine extreme sensitivity with molecular precision.

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Theoretical and computational tools to model multistable gene regulatory networks by Federico Bocci, Dongya Jia, Qing Nie, Mohit Kumar Jolly and José Onuchic (2023)

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Plutonium is considered a fascinating element. It was first chemically isolated in 1941 at the University of California, but its discovery was hidden until after the Second World War. There are six distinct allotropic phases of plutonium with very different properties. At ambient pressure, continuously increasing the temperature converts the room-temperature, simple monoclinic a phase through five phase transitions, the final one occurring at approximately 450°C.

The delta (δ) phase is perhaps the most interesting allotrope of plutonium. δ-plutonium is technologically important, has a very simple crystal structure, but its electronic structure has been debated for decades. Researchers have attempted to understand its anomalous behaviour and how the properties of δ-plutonium are connected to the 5f electrons.

The 5f electrons are found in the actinide group of elements which includes plutonium. Their behaviour is counterintuitive. They are sensitive to temperature, pressure and composition, and behave in both a localised manner, staying close to the nucleus and in a delocalised (itinerant) manner, more spread out and contributing to bonding. Both these states can support magnetism depending on actinide element. The 5f electrons contribute to δ-phase stability, anomalies in the material’s volume and bulk modulus, and to a negative thermal expansion where the δ-phase reduces in size when heated.

In this work, the researchers present a comprehensive model to predict the thermodynamic behaviour of δ-plutonium, which has a face-centred cubic structure. They use density functional theory, a computational technique that explores the overall electron density of the system and incorporate relativistic effects to capture the behaviour of fast-moving electrons and complex magnetic interactions. The model includes a parameter-free orbital polarization mechanism to account for orbital-orbital interactions, and incorporates anharmonic lattice vibrations and magnetic fluctuations, both transverse and longitudinal modes, driven by temperature-induced excitations. Importantly, it is shown that negative thermal expansion results from magnetic fluctuations.

This is the first model to integrate electronic effects, magnetic fluctuations, and lattice vibrations into a cohesive framework that aligns with experimental observations and semi-empirical models such as CALPHAD. It also accounts for fluctuating states beyond the ground state and explains how gallium composition influences thermal expansion. Additionally, the model captures the positive thermal expansion behaviour of the high-temperature epsilon phase, offering new insight into plutonium’s complex thermodynamics.

Do you want to learn more about this topic?

Pu 5f population: the case for n = 5.0 J G Tobin and M F Beaux II (2025)

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Silver iodide crystals have long been used to “seed” clouds and trigger precipitation, but scientists have never been entirely sure why the material works so well for that purpose. Researchers at TU Wien in Austria are now a step closer to solving the mystery thanks to a new study that characterized surfaces of the material in atomic-scale detail.

“Silver iodide has been used in atmospheric weather modification programs around the world for several decades,” explains Jan Balajka from TU Wien’s Institute of Applied Physics, who led this research. “In fact, it was chosen for this purpose as far back as the 1940s because of its atomic crystal structure, which is nearly identical to that of ice – it has the same hexagonal symmetry and very similar distances between atoms in its lattice structure.”

The basic idea, Balajka continues, originated with the 20^th-century American atmospheric scientist Bernard Vonnegut, who suggested in 1947 that introducing small silver iodide (AgI) crystals into a cloud could provide nuclei for ice to grow on. But while Vonnegut’s proposal worked (and helped to inspire his brother Kurt’s novel Cat’s Cradle), this simple picture is not entirely accurate. The stumbling block is that nucleation occurs at the surface of a crystal, not inside it, and the atomic structure of an AgI surface differs significantly from its interior.

A task that surface science has solved

To investigate further, Balajka and colleagues used high-resolution atomic force microscopy (AFM) and advanced computer simulations to study the atomic structure of 2‒3 nm diameter AgI crystals when they are broken into two pieces. The team’s measurements revealed that the surfaces of both freshly cleaved structures differed from those found inside the crystal.

More specifically, team member Johanna Hütner, who performed the experiments, explains that when an AgI crystal is cleaved, the silver atoms end up on one side while the iodine atoms appear on the other. This has implications for ice growth, because while the silver side maintains a hexagonal arrangement that provides an ideal template for the growth of ice layers, the iodine side reconstructs into a rectangular pattern that no longer lattice-matches the hexagonal symmetry of ice crystals. The iodine side is therefore incompatible with the epitaxial growth of hexagonal ice.

“Our works solves this decades-long controversy of the surface vs bulk structure of AgI, and shows that structural compatibility does matter,” Balajka says.

Difficult experiments

According to Balajka, the team’s experiments were far from easy. Many experimental methods for studying the structure and properties of material surfaces are based on interactions with charged particles such as electrons or ions, but AgI is an electrical insulator, which “excludes most of the tools available,” he explains. Using AFM enabled them to overcome this problem, he adds, because this technique detects interatomic forces between a sharp tip and the surface and does not require a conductive sample.

Another problem is that AgI is photosensitive and decomposes when exposed to visible light. While this property is useful in other contexts – AgI was a common ingredient in early photographic plates – it created complications for the TU Wien team. “Conventional AFM setups make use of optical laser detection to map the topography of a sample,” Balajka notes.

To avoid destroying their sample while studying it, the researchers therefore had to use a non-contact AFM based on a piezoelectric sensor that detects electrical signals and does not require optical readout. They also adapted their setup to operate in near-darkness, using only red light while manipulating the Ag to ensure that stray light did not degrade the samples.

The computational modelling part of the work introduced yet another hurdle to overcome. “Both Ag and I are atoms with a high number of electrons in their electron shells and are thus highly polarizable,” Balajka explains. “The interaction between such atoms cannot be accurately described by standard computational modelling methods such as density functional theory (DFT), so we had to employ highly accurate random-phase approximation (RPA) calculations to obtain reliable results.”

Highly controlled conditions

The researchers acknowledge that their study, which is detailed in Science Advances, was conducted under highly controlled conditions – ultrahigh vacuum, low pressure and temperature and a dark environment – that are very different from those that prevail inside real clouds. “The next logical step for us is therefore to confirm whether our findings hold under more representative conditions,” Balajka says. “We would like to find out whether the structure of AgI surfaces is the same in air and water, and if not, why.”

The researchers would also like to better understand the atomic arrangement of the rectangular reconstruction of the iodine surface. “This would complete the picture for the use of AgI in ice nucleation, as well as our understanding of AgI as a material overall,” Balajka says.

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Novel approach could be faster, and cheaper, than making the cells in the lab—but safety concerns linger

Learn about the molecules and materials found in samples of asteroid Bennu, including sugars, space gum, and an abundance of stardust.

Discover an ancient luxury shipwreck, complete with Greek graffiti, offering a rare glimpse into elite life on Alexandria’s waterways.

Learn about the first evidence of the Bronze Age plague in a non-human host, found in a sheep bone from Russia.

Learn how a major shift toward drought reshaped the Flores ecosystem and may have driven the hobbits to extinction.

Learn more about the supermassive black hole in galaxy NGC 3783 and how its powerful blast is similar to our sun’s coronal mass ejections.

Learn how male bonobos use subtle behavioral and reproductive cues to pinpoint the fertile window, even when the usual swelling signal gives them almost no useful information.

Learn more about this next chapter for Discover Magazine. 

Phil Krause applauds call by top agency official Vinay Prasad for better data, but says his approach is “destructive”

Two Shenzhou-21 astronauts embarked on the mission’s first spacewalk late Monday, inspecting and photographing a damaged spacecraft window which triggered an earlier emergency launch.

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Canada has contracted satellite operator Telesat and manufacturer MDA Space to explore options for a multibillion-dollar military communications network to support the Canadian Armed Forces in the Arctic.

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Using a novel spectroscopy technique, physicists in Japan have revealed how organic materials accumulate electrical charge through long-term illumination by sunlight – leading to material degradation. Ryota Kabe and colleagues at the Okinawa Institute of Science and Technology have shown how charge separation occurs gradually via a rare multi-photon ionization process, offering new insights into how plastics and organic semiconductors degrade in sunlight.

In a typical organic solar cell, an electron-donating material is interfaced with an electron acceptor. When the donor absorbs a photon, one of its electrons may jump across the interface, creating a bound electron-hole pair which may eventually dissociate – creating two free charges from which useful electrical work can be extracted.

Although such an interface vastly boosts the efficiency of this process, it is not necessary for charge separation to occur when an electron donor is illuminated. “Even single-component materials can generate tiny amounts of charge via multiphoton ionization,” Kabe explains. “However, experimental evidence has been scarce due to the extremely low probability of this process.”

To trigger charge separation in this way, an electron needs to absorb one or more additional photons while in its excited state. Since the vast majority of electrons fall back into their ground states before this can happen, the spectroscopic signature of this charge separation is very weak. This makes it incredibly difficult to detect using conventional spectroscopy techniques, which can generally only make observations over timescales of up to a few milliseconds.

The opposite approach

“While weak multiphoton pathways are easily buried under much stronger excited-state signals, we took the opposite approach in our work,” Kabe describes. “We excited samples for long durations and searched for traces of accumulated charges in the slow emission decay.”

Key to this approach was an electron donor called NPD. This organic material has a relatively long triplet lifetime, where an excited electron is prevented from transitioning back to its ground state. As a result, these molecules emit phosphorescence over relatively long timescales.

In addition, Kabe’s team dispersed their NPD samples into different host materials with carefully selected energy levels. In one medium, the energies of both the highest-occupied and lowest-unoccupied molecular orbitals lay below NPD’s corresponding levels, so that the host material acted as an electron acceptor. As a result, charge transfer occurred in the same way as it would across a typical donor-acceptor interface.

Yet in another medium, the host’s lowest-unoccupied orbital lay above NPD’s – blocking charge transfer, and allowing triplet states to accumulate instead. In this case, the only way for charge separation to occur was through multi-photon ionization.

Slow emission decay analysis

Since NPD’s long triplet lifetime allowed its electrons to be excited gradually over an extended period of illumination, its weak charge accumulation became detectable through slow emission decay analysis. In contrast, more conventional methods involve multiple, ultra-fast laser pulses, severely restricting the timescale over which measurements can be made. Altogether, this approach enabled the team to clearly distinguish between the two charge generation pathways.

“Using this method, we confirmed that charge generation occurred via resonance-enhanced multiphoton ionization mediated by long-lived triplet states, even in single-component organic materials,” Kabe describes.

This result offers insights into how plastics and organic semiconductors are degraded by sunlight over years or decades. The conventional explanation is that sunlight generates free radicals. These are molecules that lose an electron through ionization, leaving behind an unpaired electron which readily reacts with other molecules in the surrounding environment. Since photodegradation unfolds over such a long timescale, researchers could not observe this charge generation in single-component organic materials – until now.

“The method will be useful for analysing charge behaviour in organic semiconductor devices and for understanding long-term processes such as photodegradation that occur gradually under continuous light exposure,” Kabe says.

The research is described in Science Advances.

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With a late-rising crescent moon and early evening activity, this year’s Geminids offer some of the best viewing conditions, displaying bright, colorful streaks long before midnight. 

– SCHOTT® Solar Glass exos provides enhanced radiation resistance and optical performance for simple silicon cells up to III-V multijunction satellite solar cells.– Jointly developed with Heilbronn-based AZUR SPACE Solar […]

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Startup leans on C-band architecture to separate from L-band competitors

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Fermilab has officially opened a new building named after the particle physicist Helen Edwards. Officials from the lab and the US Department of Energy (DOE) opened the Helen Edwards Engineering Research Center at a ceremony held on 5 December.  The new building is the lab’s largest purpose-built lab and office space since the lab’s iconic Wilson Hall, which was completed in 1974.

Construction of the Helen Edwards Engineering Research Center began in 2019 and was completed three years later. The centre is an 7500 m² multi-story lab and office building that is adjacent and connected to Wilson Hall.

The new centre is designed as a collaborative lab where engineers, scientists and technicians design, build and test technologies across several areas of research such as neutrino science, particle detectors, quantum science and electronics.

The centre also features cleanrooms, vibration-sensitive labs and cryogenic facilities in which the components of the near detector for the Deep Underground Neutrino Experiment will be assembled and tested.

A pioneering spirit

With a PhD in experimental particle physics from Cornell University, Edwards was heavily involved with commissioning the university’s 10 GeV electron synchrotron. In 1970 Fermilab’s director Robert Wilson appointed Edwards as associate head of the lab’s booster section and she later became head of the accelerator division.

While at Fermilab, Edwards’ primary responsibility was designing, constructing, commissioning and operating the Tevatron, which led to the discoveries of the top quark in 1995 and the tau neutrino in 2000.

Edwards retired in the early 1990s but continued to work as guest scientists at Fermilab and officially switched the Tevatron off during a ceremony held on 30 September 2011. Edwards died in 2016.

Darío Gil, the undersecretary for science at the DOE says that Edwards’ scientific work “is a symbol of the pioneering spirit of US research”.

“Her contributions to the Tevatron and the lab helped the US become a world leader in the study of elementary particles,” notes Gil. “We honour her legacy by naming this research centre after her as Fermilab continues shaping the next generation of research using [artificial intelligence], [machine learning] and quantum physics.”

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Learn more about the science behind the belief that we can “see” better while driving when we turn the music down.

LeoLabs has won an interagency contract to provide space-surveillance data for the U.S. government, supporting adversarial spacecraft monitoring and the TraCSS orbital traffic coordination platform due to enter full service early next year.

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It has become conventional wisdom that China’s rise is driven by a coordinated strategy across three fronts here on Earth: dominating critical industries, controlling critical resources and occupying strategically important locations. This is explicit in the Chinese Communist Party’s own planning documents, speeches and industrial policies. We now face the same strategy pointed upward. Beijing […]

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The company is adapting commercial thermal-sensing tech for military applications

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Space-based solar power startup Aetherflux has thrown its hat into the emerging market for orbital data centers, joining SpaceX, Amazon and others exploring ways to move energy-hungry artificial intelligence compute off Earth.

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