For nearly 80 years, the specter of nuclear war has haunted humankind, shaping foreign policy, military strategy, and international relations. The principle of “mutually assured destruction” (MAD) has been the cornerstone of global stability since the dawn of the atomic age. Yet, this fragile equilibrium has always depended on one terrifying certainty: No defense is […]
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Measuring blood flow to the brain is essential for diagnosing and developing treatments for neurological disorders such as stroke, vascular dementia or traumatic brain injury. Performing this measurement non-invasively is challenging, however, and achieved predominantly using costly MRI and nuclear medicine imaging techniques.
Emerging as an alternative, modalities based on optical transcranial measurement are cost-effective and easy to use. In particular, speckle contrast optical spectroscopy (SCOS) – an offshoot of laser speckle contrast imaging, which uses laser light speckles to visualize blood vessels – can measure cerebral blood flow (CBF) with high temporal resolution, typically above 30 Hz, and cerebral blood volume (CBV) through optical signal attenuation.
Researchers at the California Institute of Technology (Caltech) and the Keck School of Medicine’s USC Neurorestoration Center have designed a lightweight SCOS system that accurately measures blood flow to the brain, distinguishing it from blood flow to the scalp. Co-senior author Charles Liu of the Keck School of Medicine and team describe the system and their initial experimentation with it in APL Bioengineering.
Seven simultaneous measurements Detection channels with differing source-to-detector distances monitor blood dynamics in the scalp, skull and brain layers. (Courtesy: CC BY 4.0/APL Bioeng. 10.1063/5.0263953)
The SCOS system consists of a 3D-printed head mount designed for secure placement over the temple region. It holds a single 830 nm laser illumination fibre and seven detector fibres positioned at seven different source-to-detector (S–D) distances (between 0.6 and 2.6 cm) to simultaneously capture blood flow dynamics across layers of the scalp, skull and brain. Fibres with shorter S–D distances acquire shallower optical data from the scalp, while those with greater distances obtain deeper and broader data. The seven channels are synchronized to exhibit identical oscillation frequencies corresponding to the heart rate and cardiac cycle.
When the SCOS system directs the laser light onto a sample, multiple random scattering events occur before the light exits the sample, creating speckles. These speckles, which materialize on rapid timescales, are the result of interference of light travelling along different trajectories. Movement within the sample (of red blood cells, for instance) causes dynamic changes in the speckle field. These changes are captured by a multi-million-pixel camera with a frame rate above 30 frames/s and quantified by calculating the speckle contrast value for each image.
Human testing
The researchers used the SCOS system to perform CBF and CBV measurements in 20 healthy volunteers. To isolate and obtain surface blood dynamics from brain signals, the researchers gently pressed on the superficial temporal artery (a terminal branch of the external carotid artery that supplies blood to the face and scalp) to block blood flow to the scalp.
In tests on the volunteers, when temporal artery blood flow was occluded for 8 s, scalp-sensitive channels exhibited significant decreases in blood flow while brain-sensitive channels showed minimal change, enabling signals from the internal carotid artery that supplies blood to the brain to be clearly distinguished. Additionally, the team found that positioning the detector 2.3 cm or more away from the source allowed for optimal brain blood flow measurement while minimizing interference from the scalp.
“Combined with the simultaneous measurements at seven S–D separations, this approach enables the first quantitative experimental assessment of how scalp and brain signal contributions vary with depth in SCOS-based CBF measurements and, more broadly, in optical measurements,” they write. “This work also provides crucial insights into the optimal device S–D distance configuration for preferentially probing brain signal over scalp signal, with a practical and subject-friendly alternative for evaluating depth sensitivity, and complements more advanced, hardware-intensive strategies such as time-domain gating.”
The researchers are now working to improve the signal-to-noise ratio of the system. They plan to introduce a compact, portable laser and develop a custom-designed extended camera that spans over 3 cm in one dimension, enabling simultaneous and continuous measurement of blood dynamics across S–D distances from 0.5 to 3.5 cm. These design advancements will enhance spatial resolution and enable deeper brain measurements.
“This crucial step will help transition the system into a compact, wearable form suitable for clinical use,” comments Liu. “Importantly, the measurements described in this publication were achieved in human subjects in a very similar manner to how the final device will be used, greatly reducing barriers to clinical application.”
“I believe this study will advance the engineering of SCOS systems and bring us closer to a wearable, clinically practical device for monitoring brain blood flow,” adds co-author Simon Mahler, now at Stevens Institute of Technology. “I am particularly excited about the next stage of this project: developing a wearable SCOS system that can simultaneously measure both scalp and brain blood flow, which will unlock many fascinating new experiments.”
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As the International Year of Quantum Science and Technology (IYQ) draws to a close, I hope you’ve enjoyed our extensive quantum coverage over the last 12 months. We’ve tackled the history of the subject, explored some of the unexplained mysteries that still make quantum physics so exciting, and examined many of the commercial applications of quantum technology. You can find most of our coverage collected into two free-to-read digital Quantum Briefings, available here and here on the Physics World website.
Over the last 100 years since Werner Heisenberg first developed quantum mechanics on the island of Helgoland in June 1925, quantum mechanics has proved to be an incredibly powerful, successful and logically consistent theory. Our understanding of the subatomic world is no longer the “lamentable hodgepodge of hypotheses, principles, theorems and computational recipes”, as the Israeli physicist and philosopher Max Jammer memorably once described it.
In fact, quantum mechanics has not just transformed our understanding of the natural world; it has immense practical ramifications too, with so-called “quantum 1.0” technologies – lasers, semiconductors and electronics – underpinning our modern world. But as was clear from the UK National Quantum Technologies Showcase in London last week, organized by Innovate UK, the “quantum 2.0” revolution is now in full swing.
The day-long event, which is now in its 10th year, featured over 100 exhibitors, including many companies that are already using fundamental quantum concepts such as entanglement and superposition to support the burgeoning fields of quantum computing, quantum sensing and quantum communication. The show was attended by more than 3000 delegates, some of whom almost had to be ushered out of the door at closing time, so keen were they to keep talking.
The first day, focusing on the foundations of quantum mechanics, included a panel discussion with physicists Fay Dowker (Imperial College), Jim Al-Khalili (University of Surrey) and Peter Knight. They talked about whether the quantum wavefunction provides a complete description of physical reality, prompting much discussion with the audience. As Al-Khalili wryly noted, if entanglement has emerged as the fundamental feature of quantum reality, then “decoherence is her annoying and ever-present little brother”.
Knight, meanwhile, who is a powerful figure in quantum-policy circles, went as far as to say that the limit of decoherence – and indeed the boundary between the classical and quantum worlds – is not a fixed and yet-to-be revealed point. Instead, he mused, it will be determined by how much money and ingenuity and time physicists have at their disposal.
On the second day of the IOP conference at the RI, I chaired a debate that brought together four future leaders of the subject: Mehul Malik (Heriot-Watt University) and Sarah Malik (University College London) along with industry insiders Nicole Gillett (Riverlane) and Muhammad Hamza Waseem (Quantinuum).
As well as outlining the technical challenges in their fields, the speakers all stressed the importance of developing a “skills pipeline” so that the quantum sector has enough talented people to meet its needs. Also vital will be the need to communicate the mysteries and potential of quantum technology – not just to the public but to industrialists, government officials and venture capitalists. By many measures, the UK is at the forefront of quantum tech – and it is a lead it should not let slip.
Clear talker Jim Al-Khalili giving his Friday night discourse at the Royal Institution on 7 November 2025. (Courtesy: Matin Durrani)
The week ended with Al-Khalili giving a public lecture, also at the Royal Institution, entitled “A new quantum world: ‘spooky’ physics to tech revolution”. It formed part of the RI’s famous Friday night “discourses”, which this year celebrate their 200th anniversary. Al-Khalili, who also presents A Life Scientific on BBC Radio 4, is now the only person ever to have given three RI discourses.
After the lecture, which was sold out, he took part in a panel discussion with Knight and Elizabeth Cunningham, a former vice-president for membership at the IOP. Al-Khalili was later presented with a special bottle of “Glentanglement” whisky made by Glasgow-based Fraunhofer UK for the Scottish Quantum Technology cluster.
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