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New quantum-enabled proteins could improve biosensing

A new class of biomolecules called magneto-sensitive fluorescent proteins, or MFPs, could improve imaging of biological processes inside living cells and potentially underpin innovative therapies.

The fluorescent proteins commonly used in biological studies respond solely to light being shone at them. But because that light gets scattered by tissues there are inaccuracies in determining exactly where the resulting fluorescence originates. By contrast, the MFPs created by a team led by Harrison Steel, head of the Engineered Biotechnology Research Group at the University of Oxford in the UK, fluoresce partly in response to highly predictable magnetic fields and radio waves that pass through biological tissues without deflection.

Schematic showing MFP sensor operation
Sensor schematic An MFP excited by blue light emits green fluorescence, the intensity of which can be modulated by applying appropriate magnetic or radiofrequency fields. (Courtesy: Gabriel Abrahams)

To detect where MFPs are located within living cells, the researchers apply both a static magnetic field with a precisely known gradient and a radiofrequency (RF) signal, which modulate the fluorescence triggered via excitation by a light-emitting diode (LED).

The emitted fluorescence is brightest whenever the RF is in resonance with a transition energy of the entangled electron system present within the MFP. Since the resonance frequency depends on the surrounding magnetic field strength, the brightness reveals the protein’s location.

As detailed in their recent Nature paper, the researchers engineered the MFPs by “directed evolution”: starting with a DNA sequence, making two to three thousand variants of it, and selecting the variants with the best fluorescence response to magnetic fields before repeating the entire process multiple times. The resulting proteins were tested via ODMR (optically detected magnetic resonance) and MFE (magnetic-field effect) experiments, revealing that they could be detected in single living cells and sense their local microenvironment.

Importantly, these MFPs can be made in research labs using a straightforward biological technique. “This is a totally different way of coming up with new quantum materials compared to other engineering efforts for quantum sensors like nitrogen vacancies [in diamonds] which need to be manufactured in highly specialized facilities,” explains first author Gabriel Abrahams, a doctoral student in Steel’s research group. Abrahams helped develop quantum diamond microscopes during his master’s in physics at the Quantum Nano Sensing Lab in Melbourne, Australia before moving onto the Oxford Interdisciplinary Bioscience Doctoral Training Programme.

The MFPs were inspired by the work of study co-authors Maria Ingaramo and Andy York, both then working for Calico Life Sciences. They had observed a small change in fluorescence when a magnet interacted with a quantum-enabled protein, explains Abrahams. “That was really cool! I hadn’t seen anything like that, and there were clearly potential applications if it could be made better,” he says.

Steel tells Physics World that “a lot of the past work in quantum biology was with fragile proteins, often at cryogenic temperatures. Surprisingly you could easily measure these MFPs in single living cells every few minutes as they can work for a long time at room temperature”. Furthermore, using MFPs only requires adding a magnet to existing fluorescence microscopy equipment, allowing new data to be cost-effectively obtained.

“For instance, you might use three or four fluorescent proteins to tag natural processes in a mammalian cell in a petri dish to see when they are being used and where they go. We could instead tag with 10 or 15 MFPs, allowing you to measure extra targets by just applying a magnetic field,” Steel explains.

Quantum engineer Peter Maurer from the University of Chicago in the US, who was not involved in the study, is enthusiastic about these new MFPs. “By combining magnetic fields and fluorescence, this work establishes an exciting new imaging modality with broad potential for future evolution. Notably, similar approaches could be directly applicable to qubits [quantum bits], such as the fluorescent protein qubits our team published in Nature last year,” he says.

Next, Steel intends to improve their instrumentation for using MFPs – much of which was adopted from researchers investigating how birds navigate via the earth’s magnetic field. Future MFP applications could include microbiome studies sensing where bacteria travel in our bodies, and the development of highly controllable actuators for drug delivery. “If you would like to turn on the protein’s ability to bind to a cancer cell, for example, you could simply put a magnet on the outside of a person in the right location,” he concludes.

The post New quantum-enabled proteins could improve biosensing appeared first on Physics World.

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Integrate Raises $17M to Commercialize the World’s First Ultra-Secure Project Management Platform for Classified Programs

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SEATTLE, Feb. 11, 2026 — Integrate, the developer of the world’s first ultra-secure project management platform for dynamic multi-entity execution, today announced a $17 million Series A raise led by FPV Ventures with participation from Fuse […]

The post Integrate Raises $17M to Commercialize the World’s First Ultra-Secure Project Management Platform for Classified Programs appeared first on SpaceNews.

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Duke of Edinburgh informed about physics and the green economy at visit to Institute of Physics in London

Four photos of Prince Edward at the IOP's "Physics Powering the Green Economy" event
Royal approval (Clockwise from top left) The Duke of Edinburgh with IOP group chief executive Tom Grinyer; talking to Selina Ambrose from Promethean Particles; the exhibition he toured; and speaking after the panel debate. (Courtesy: Carmen Valino)

The Duke of Edinburgh visited the headquarters of the Institute of Physics (IOP) in central London on 5 February to learn about the role that physics plays in supporting the green economy.

The event was attended by about 100 business leaders, policy chiefs, senior physicists, and IOP and IOP Publishing staff. It highlighted how physics research is helping to deliver clean energy solutions and support economic growth.

A total of 12 companies took part in an exhibition that was visited by the duke. They included two carbon-capture firms – Nellie Technologies and Promethean Particles – as well as the fusion firm Tokamak Energy and Sunamp, which makes non-flammable “thermal batteries”.

The other firms were Intelligent Energy, Matoha Instrumentation, NESO, Oxford Instruments, Inductive Power Projection, QBA, Reclinker and Treeconomy.

The event included a panel debate chaired by Tara Shears, the IOP’s vice-president for science and innovation.

It featured ex-BP boss John Browne, who now works in green energy, along with Sizewell C energy-strategy director David Cole, Nellie Technologies founder Stephen Millburn, solar-cell physicist Jenny Nelson from Imperial College, and Emily Nurse from the UK’s Climate Change Committee.

After the debate, the duke said the event had showcased “some of the brilliant ideas that are trying to solve some really challenging issues through creativity and imagination”. He expressed particular delight that people are central to that mission.

“Our ability to evolve the right skills for the future has been well demonstrated here,” he said. “It comes down to creating the right climate to allow these ideas to flourish and come to market. We simply cannot drop this issue.”

Tom Grinyer, group chief executive of the IOP, reminded delegates that physics is fundamental to the UK economy. “We’re seeing how research is translating into real-world solutions that matter today, from clean power and climate intelligence, to advanced materials and future technologies,” he said.

But he warned that long-term investment in young people will be vital to create the physicists and business leaders who can tackle those challenges.

The post Duke of Edinburgh informed about physics and the green economy at visit to Institute of Physics in London appeared first on Physics World.

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Motiv Space Systems and PickNik Robotics Collaborate on Software for NASA’s Fly Foundational Robotics (FFR) Mission

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Boulder, CO and Pasadena, CA — February 11, 2026 — Motiv Space Systems announced a contractual agreement with PickNik Robotics to support software development for NASA’s Fly Foundational Robotics (FFR) […]

The post Motiv Space Systems and PickNik Robotics Collaborate on Software for NASA’s Fly Foundational Robotics (FFR) Mission appeared first on SpaceNews.

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