With the demand for human donor organs desperately outstripping supply, scientists are working to see if genetically edited pig organs can bridge the gap.
This episode of Physics World Stories features an interview with Jessica Esquivel and Emily Esquivel – the creative duo behind Queer Quest. The event created a shared space for 2SLGBTQIA+ Black and Brown people working in science, technology, engineering, arts and mathematics (STEAM).
Mental Health professionals also joined Queer Quest, which was officially recognised by UNESCO as part of the International Year of Quantum Science and Technology (IYQ). Over two days in Chicago this October, the event brought science, identity and wellbeing into powerful conversation.
Jessica Esquivel, a particle physicist and associate scientist at Fermilab, is part of the Muon g-2 experiment, pushing the limits of the Standard Model. Emily Esquivel is a licensed clinical professional counsellor. Together, they run Oyanova, an organization empowering Black and Brown communities through science and wellness.
Quantum metaphors and resilience through connection
Courtesy: Oyanova
Queer Quest blended keynote talks, with collective conversations, alongside meditation and other wellbeing activities. Panellists drew on quantum metaphors – such as entanglement – to explore identity, community and mental health.
In a wide-ranging conversation with podcast host Andrew Glester, Jessica and Emily speak about the inspiration for the event, and the personal challenges they have faced within academia. They speak about the importance of building resilience through community connections, especially given the social tensions in the US right now.
Imaging buried objects Left: artistic impression of metal spheres buried in small glass beads; centre: conventional ultrasound image; right: the new technology can precisely determine the positions of the metal spheres. (Courtesy: TU Wien/Arthur Le Ber)
Physicists have developed a novel imaging technique for detecting and characterizing objects hidden within opaque, highly scattering material. The researchers, from France and Austria, showed that their new mathematical approach, which utilizes the fact that hidden objects generate their own complex scattering pattern, or “fingerprint”, can work on biological tissue.
Viewing the inside of the human body is challenging due to the scattering nature of tissue. With ultrasound, when waves propagate through tissue they are reflected, bounce around and scatter chaotically, creating noise that obscures the signal from the object that the medical practitioner is trying to see. The further you delve into the body the more incoherent the image becomes.
There are techniques for overcoming these issues, but as scattering increases – in more complex media or as you push deeper through tissue – they struggle and unpicking the required signal becomes too complex.
The scientists behind the latest research, from the Institut Langevin in Paris, France and TU Wien in Vienna, Austria, say that rather than compensating for scattering, their technique instead relies on detecting signals from the hidden object in the disorder.
Objects buried in a material create their own complex scattering pattern, and the researchers found that if you know an object’s specific acoustic signal it’s possible to find it in the noise created by the surrounding environment.
“We cannot see the object, but the backscattered ultrasonic wave that hits the microphones of the measuring device still carries information about the fact that it has come into contact with the object we are looking for,” explains Stefan Rotter, a theoretical physicist at TU Wien.
Rotter and his colleagues examined how a series of objects scattered ultrasound waves in an interference-free environment. This created what they refer to as fingerprint matrices: measurements of the specific, characteristic way in which each object scattered the waves.
The team then developed a mathematical method that allowed them to calculate the position of each object when hidden in a scattering medium, based on its fingerprint matrix.
“From the correlations between the measured reflected wave and the unaltered fingerprint matrix, it is possible to deduce where the object is most likely to be located, even if the object is buried,” explains Rotter.
The team tested the technique in three different scenarios. The first experiment trialled the ultrasound imaging of metal spheres in a dense suspension of glass beads in water. Conventional ultrasound failed in this setup and the spheres were completely invisible, but with their novel fingerprint method the researchers were able to accurately detect them.
Next, to examine a medical application for the technique, the researchers embedded lesion markers often used to monitor breast tumours in a foam designed to mimic the ultrasound scattering of soft tissue. These markers can be challenging to detect due to scatterers randomly distributed in human tissue. With the fingerprint matrix, however, the researchers say that the markers were easy to locate.
Finally, the team successfully mapped muscle fibres in a human calf using the technique. They claim this could be useful for diagnosing and monitoring neuromuscular diseases.
According to Rotter and his colleagues, their fingerprint matrix method is a versatile and universal technique that could be applied beyond ultrasound to all fields of wave physics. They highlight radar and sonar as examples of sensing techniques where target identification and detection in noisy environments are long-standing challenges.
“The concept of the fingerprint matrix is very generally applicable – not only for ultrasound, but also for detection with light,” Rotter says. “It opens up important new possibilities in all areas of science where a reflection matrix can be measured.”
The researchers report their findings in Nature Physics.
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Iridium Communications plans to release a tiny chip next year to protect devices relying on navigation satellites from jamming and spoofing, reinforcing one of the L-band operator’s core strengths as SpaceX’s Starlink encroaches on other parts of its business.
AI is changing what careers are possible for students interested in STEM subjects. WIRED spoke with five aspiring scientists to find out how they’re preparing for the future.
Obviously, I write: I wouldn’t be a very good science writer if I couldn’t. So communication skills are vital. Recently, for example, Qruise launched a new magnetic-resonance product for which I had to write a press release, create a new webpage and do social-media posts. That meant co-ordinating with lots of different people, finding out the key features to advertise, identifying the claims we wanted to make – and if we have the data to back those claims up. I’m not an expert in quantum computing or magnetic-resonance imagining or even marketing so I have to pick things up fast and then translate technically complex ideas from physics and software into simple messages for a broader audience. Thankfully, my colleagues are always happy to help. Science writing is a difficult task but I think I’m getting better at it.
What do you like best and least about your job?
I love the variety and the fact that I’m doing so many different things all the time. If there’s a day I feel I want something a little bit lighter, I can do some social media or the website, which is more creative. On the other hand, if I feel I could really focus in detail on something then I can write some documentation that is a little bit more technical. I also love the flexibility of remote working, but I do miss going to the office and socialising with my colleagues on a regular basis. You can’t get to know someone as well online, it’s nicer to have time with them in person.
What do you know today, that you wish you knew when you were starting out in your career?
That’s a hard one. It would be easy to say I wish I’d known earlier that I could combine science and writing and make a career out of that. On the other hand, if I’d known that, I might not have done my PhD – and if I’d gone into writing straight after my undergraduate degree, I perhaps wouldn’t be where I am now. My point is, it’s okay not to have a clear plan in life. As children, we’re always asked what we want to be – in my case, my dream from about the age of four was to be a vet. But then I did some work experience in a veterinary practice and I realized I’m really squeamish. It was only when I was 15 or 16 that I discovered I wanted to do physics because I liked it and was good at it. So just follow the things you love. You might end up doing something you never even thought was an option.
This is the story of two people—and their ChatGPT companions—trying to improve their lives through AI. These relationships, it is clear, are changing us.
Future versions of the Laser Interferometer Gravitational Wave Observatory (LIGO) will be able to run at much higher laser powers thanks to a sophisticated new system that compensates for temperature changes in optical components. Known as FROSTI (for FROnt Surface Type Irradiator) and developed by physicists at the University of California Riverside, US, the system will enable next-generation machines to detect gravitational waves emitted when the universe was just 0.1% of its current age, before the first stars had even formed.
Gravitational waves are distortions in spacetime that occur when massive astronomical objects accelerate and collide. When these distortions pass through the four-kilometre-long arms of the two LIGO detectors, they create a tiny difference in the (otherwise identical) distance that light travels between the centre of the observatory and the mirrors located at the end of each arm. The problem is that detecting and studying gravitational waves requires these differences in distance to be measured with an accuracy of 10-19 m, which is 1/10 000th the size of a proton.
Observing waves at lower and higher frequencies in the gravitational wave spectrum remains challenging, however. At lower frequencies (around 10–30 Hz), the problem stems from vibrational noise in the mirrors. Although these mirrors are hefty objects – each one measures 34 cm across, is 20 cm thick and has a mass of around 40 kg – the incredible precision required to detect gravitational waves at these frequencies means that even the minute amount of energy they absorb from the laser beam is enough to knock them out of whack.
At higher frequencies (150 – 2000 Hz), measurements are instead limited by quantum shot noise. This is caused by the random arrival time of photons at LIGO’s output photodetectors and is a fundamental consequence of the fact that the laser field is quantized.
A novel adaptive optics device
Jonathan Richardson, the physicist who led this latest study, explains that FROSTI is designed to reduce quantum shot noise by allowing the mirrors to cope with much higher levels of laser power. At its heart is a novel adaptive optics device that is designed to precisely reshape the surfaces of LIGO’s main mirrors under laser powers exceeding 1 megawatt (MW), which is nearly five times the power used at LIGO today.
Though its name implies cooling, FROSTI actually uses heat to restore the mirror’s surface to its original shape. It does this by projecting infrared radiation onto test masses in the interferometer to create a custom heat pattern that “smooths out” distortions and so allows for fine-tuned, higher-order corrections.
The single most challenging aspect of FROSTI’s design, and one that Richardson says shaped its entire concept, is the requirement that it cannot introduce even more noise into the LIGO interferometer. “To meet this stringent requirement, we had to use the most intensity-stable radiation source available – that is, an internal blackbody emitter with a long thermal time constant,” he tells Physics World. “Our task, from there, was to develop new non-imaging optics capable of reshaping the blackbody thermal radiation into a complex spatial profile, similar to one that could be created with a laser beam.”
Richardson anticipates that FROSTI will be a critical component for future LIGO upgrades – upgrades that will themselves serve as blueprints for even more sensitive next-generation observatories like the proposed Cosmic Explorer in the US and the Einstein Telescope in Europe. “The current prototype has been tested on a 40-kg LIGO mirror, but the technology is scalable and will eventually be adapted to the 440-kg mirrors envisioned for Cosmic Explorer,” he says.
Jan Harms, a physicist at Italy’s Gran Sasso Science Institute who was not involved in this work, describes FROSTI as “an ingenious concept to apply higher-order corrections to the mirror profile.” Though it still needs to pass the final test of being integrated into the actual LIGO detectors, Harms notes that “the results from the prototype are very promising”.
Richardson and colleagues are continuing to develop extensions to their technology, building on the successful demonstration of their first prototype. “In the future, beyond the next upgrade of LIGO (A+), the FROSTI radiation will need to be shaped into an even more complex spatial profile to enable the highest levels of laser power (1.5 MW) ultimately targeted,” explains Richardson. “We believe this can be achieved by nesting two or more FROSTI actuators together in a single composite, with each targeting a different radial zone of the test mass surfaces. This will allow us to generate extremely finely-matched optical wavefront corrections.”
Australian company HEO has imaged and modeled a mystery Chinese satellite prior to its reentry into Earth’s atmosphere, revealing previously unknown details about the spacecraft.
The defense and intelligence community is entering a new era of autonomy, one defined by AI-driven workflows that are reshaping how we handle geospatial intelligence (GEOINT). Agents are beginning to […]
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Japan launched the first of a new generation of cargo spacecraft to the International Space Station, with potential applications beyond low Earth orbit.
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