Spending time in space has a big impact on the human body and can cause a range of health issues. Many astronauts develop vision problems because microgravity causes body fluids to redistribute towards the head. This can lead to swelling in the eye and compression of the optic nerve.
While eye conditions can generally be treated with medication, delivering drugs in space is not a straightforward task. Eye drops simply don’t work without gravity, for example. To address this problem, researchers in Hungary are developing a tiny dissolvable eye insert that could deliver medication directly to the eye. The size of a grain of rice, the insert has now been tested by an astronaut on the International Space Station.
This episode of the Physics World Weekly podcast features two of those researchers – Diána Balogh-Weiser of Budapest University of Technology and Economics and Zoltán Nagy of Semmelweis University – who talk about their work with Physics World’s Tami Freeman.
The composite shielding designed to protect spacecraft from debris impact was developed by Atomic-6 under a U.S. Space Force Small Business Innovation Research contract
Researchers in Japan and Taiwan have captured three-dimensional images of an entire geothermal system deep in the Earth’s crust for the first time. By mapping the underground distribution of phenomena such as fracture zones and phase transitions associated with seismic activity, they say their work could lead to improvements in earthquake early warning models. It could also help researchers develop next-generation versions of geothermal power – a technology that study leader Takeshi Tsuji of the University of Tokyo says has enormous potential for clean, large-scale energy production.
“With a clear three-dimensional image of where supercritical fluids are located and how they move, we can identify promising drilling targets and design safer and more efficient development plans,” Tsuji says. “This could have direct implications for expanding geothermal power generation, reducing dependence on fossil fuels, and contributing to carbon neutrality and energy security in Japan and globally.”
In their study, Tsuji and colleagues focused on a region known as the brittle-ductile transition zone, which is where rocks go from being seismically active to mostly inactive. This zone is important for understanding volcanic activity and geothermal processes because it lies near an impermeable sealing band that allows fluids such as water to accumulate in a high-pressure, supercritical state. When these fluids undergo phase transitions, earthquakes may follow. However, such fluids could also produce more geothermal energy than conventional systems. Identifying their location is therefore important for this reason, too.
A high-resolution “digital map”
Many previous electromagnetic and magnetotelluric surveys suffered from low spatial resolution and were limited to regions relatively close to the Earth’s surface. In contrast, the techniques used in the latest study enabled Tsuji and colleagues to create a clear high-resolution “digital map” of deep geothermal reservoirs – something that has never been achieved before.
To make their map, the researchers used three-dimensional multichannel seismic surveys to image geothermal structures in the Kuju volcanic group, which is located on the Japanese island of Kyushu. They then analysed these images using a method they developed known as extended Common Reflection Surface (CRS) stacking. This allowed them to visualize deeper underground features such as magma-related structures, fracture-controlled fluid pathways and rock layers that “seal in” supercritical fluids.
“In addition to this, we applied advanced seismic tomography and machine-learning based analyses to determine the seismic velocity of specific structures and earthquake mechanisms with high accuracy,” explains Tsuji. “It was this integrated approach that allowed us to image a deep geothermal system in unprecedented detail.” He adds that the new technique is also better suited to mountainous geothermal regions where limited road access makes it hard to deploy the seismic sources and receivers used in conventional surveys.
A promising site for future supercritical geothermal energy production
Tsuji and colleagues chose to study the Kuju area because it is home to several volcanoes that were active roughly 1600 years ago and have erupted intermittently in recent years. The region also hosts two major geothermal power plants, Hatchobaru and Otake. The former has a capacity of 110 MW and is the largest geothermal facility in Japan.
The heat source for both plants is thought to be located beneath Mt Kuroiwa and Mt Sensui, and the region is considered a promising site for supercritical geothermal energy production. Its geothermal reservoir appears to consist of water that initially fell as precipitation (so-called meteoric water) and was heated underground before migrating westward through the fault system. Until now, though, no detailed images of the magmatic structures and fluid pathways had been obtained.
Tsuji says he has long wondered why geothermal power is not more widely used in Japan, despite the country’s abundant volcanic and thermal resources. “Our results now provide the scientific and technical foundation for next-generation supercritical geothermal power,” he tells Physics World.
The researchers now plan to try out their technique using portable seismic sources and sensors deployed in mountainous areas (not just along roads) to image the shallower parts of geothermal systems in greater detail as well. “We also plan to extend our surveys to other geothermal fields to test the general applicability of our method,” Tsuji says. “Ultimately, our goal is to provide a reliable scientific basis for the large-scale deployment of supercritical geothermal power as a sustainable energy source.”
HELSINKI — China added to its Guowang national broadband megaconstellation Wednesday with the 600th Long March rocket launch, marking a milestone in the country’s accelerating spaceflight cadence. A Long March 8A rocket lifted off at 9:33 p.m. Eastern, Oct. 15 (0133 UTC, Oct. 16) from launch pad 1 at the Hainan Commercial Space Launch Center […]
A research team in Sweden has used real-time imaging technology to visualize the way that blood pumps around a pulsating artificial heart – moving medicine one step closer to the safe use of such devices in people waiting for donor transplants.
The Linköping University (LiU) team used 4D flow MRI to examine the internal processes of a mechanical heart prototype created by Västerås-based technology company Scandinavian Real Heart. The researchers evaluated blood flow patterns and compared them with similar measurements taken in a native human heart, outlining their results in Scientific Reports.
“As the pulsatile total artificial heart contains metal parts, like the motor, we used 3D printing [to replace most metal parts] and a physiological flow loop so we could run it in the MRI scanner under representable conditions,” says first author Twan Bakker, a PhD student at the Center for Medical Image Science and Visualization at LiU.
No elevated risk
According to Bakker, this is first time that a 3D-printed MRI-compatible artificial heart has been built and successfully evaluated using 4D flow MRI. The team was pleased to discover that the results corroborate the findings of previous computational fluid dynamics simulations indicating “low shear stress and low stagnation”. Overall flow patterns also suggest there is no elevated risk for blood complications compared with hearts in healthy humans and those suffering from valvular disease.
“[The] patterns of low blood flow, a risk for thrombosis, were in the same range as for healthy native human hearts. Patterns of turbulent flow, a risk for activation of blood platelets, which can contribute to thrombosis, were lower than those found in patients with valvular disease,” says Bakker.
“4D flow MRI allows us to measure the flow field without altering the function of the total artificial heart, which is therefore a valuable tool to complement computer simulations and blood testing during the development of the device. Our measurements provided valuable information to the design team that could improve the artificial heart prototype further,” he adds.
Improved diagnostics
A key advantage of 4D flow MRI over alternative measurement techniques – such as particle image velocimetry and laser doppler anemometry – is that it doesn’t require the creation of a fully transparent model. This is an important distinction for Bakker, since some components in the artificial heart are made with materials possessing unique mechanical properties, meaning that replication in a see-through version would be extremely challenging.
Visualizing blood flow The central image shows a representation of the full cardiac cycle in the artificial heart, with circulating flow patterns in various locations highlighted at specified time points. (Courtesy: CC BY 4.0/Sci. Rep. 10.1038/s41598-025-18422-y)
“With 4D flow MRI we had to move the motor away from the scanner bore, but the material in contact with the blood and the motion of the device remained as the original design,” says Bakker.
According to Bakker, the velocity measurements can also be used for visualization and analysis of hemodynamic parameters, such as turbulent kinetic energy, wall shear stresses and more in the heart, as well as for larger vessels in our bodies.
“By studying the flow dynamics in patients and healthy subjects, we can better understand its role in health and disease, which can then support improved diagnostics, interventions and surgical therapies,” he explains.
Moving forward, Bakker says that the research team will continue to evaluate the improved heart design, which was recently granted designation as a Humanitarian Use Device (HUD) by the US Food and Drug Administration (FDA).
“This makes it possible to apply for designation as a Humanitarian Device Exemption (HDE) – which may grant the device limited marketing rights and paves the way for the pre-clinical and clinical studies,” he says.
“In addition, we are currently developing tools to compute blood flow using simulations. This may provide us with a deeper understanding of the mechanisms that cause the formation of thrombosis and haemolysis,” he tells Physics World.
Five years after the first countries signed the Artemis Accords, a growing group of nations continues to work on how to implement the guidelines contained in the document.
This was the second plane of satellites for Tranche 1 of the Transport Layer, part of a planned global network of data transport and sensor satellites known as the Proliferated Warfighter Space Architecture
Observe the fiery Southern and Northern Taurids, a pair of potentially flashy meteor showers that are set to peak this November 2025, all thanks to the debris of an ancient comet.
Learn how an unconventional folk cure landed one woman in the hospital, yet the idea that frogs hold pain-relieving powers isn’t as far-fetched as it sounds.
Every new space mission runs into the same wall: physics and fragility. Physics, because the speed of light and contested spectrum make real-time decision-making from the ground impossible when you need it most. Fragility, because modern space systems are software-defined, interconnected, and therefore exposed to radiation-induced faults, cascading anomalies and increasingly sophisticated cyber threats. The […]
Beyond Gravity is weighing expanding solar array drive mechanism production in Florida to support Golden Dome and other U.S. space projects, after doubling manufacturing space in Europe for hardware that keeps satellites pointed toward the sun.
WARSAW — The Polish optical systems manufacturer Scanway Space has secured its first order from an American company, in this case from Intuitive Machines for a multispectral telescope instrument to map the moon’s surface. Scanway CEO Jędrzej Kowalewski told SpaceNews the optical instrument, set to be launched in 2026, will allow Intuitive Machines to search […]
Adaptive radiation therapy (ART) is a personalized cancer treatment in which a patient’s treatment plan can be updated throughout their radiotherapy course to account for any anatomical variations – either between fractions (offline ART) or immediately prior to dose delivery (online ART). Using high-fidelity images to enable precision tumour targeting, ART improves outcomes while reducing side effects by minimizing healthy tissue dose.
Elekta, the company behind the Unity MR-Linac, believes that in time, all radiation treatments will incorporate ART as standard. Towards this goal, it brings its broad knowledge base from the MR-Linac to the new Elekta Evo, a next-generation CT-Linac designed to improve access to ART. Evo incorporates AI-enhanced cone-beam CT (CBCT), known as Iris, to provide high-definition imaging, while its Elekta ONE Online software automates the entire workflow, including auto-contouring, plan adaptation and end-to-end quality assurance.
A world first
In February of this year, Matthias Lampe and his team at the private centre DTZ Radiotherapy in Berlin, Germany became the first in the world to treat patients with online ART (delivering daily plan updates while the patient is on the treatment couch) using Evo. “To provide proper tumour control you must be sure to hit the target – for that, you need online ART,” Lampe tells Physics World.
Initiating online ART The team at DTZ Radiotherapy in Berlin treated the first patient in the world using Evo. (Courtesy: Elekta)
The ability to visualize and adapt to daily anatomy enables reduction of the planning target volume, increasing safety for nearby organs-at-risk (OARs). “It is highly beneficial for all treatments in the abdomen and pelvis,” says Lampe. “My patients with prostate cancer report hardly any side effects.”
Lampe selected Evo to exploit the full flexibility of its C-arm design. He notes that for the increasingly prevalent hypofractionated treatments, a C-arm configuration is essential. “CT-based treatment planning and AI contouring opened up a new world for radiation oncologists,” he explains. “When Elekta designed Evo, they enabled this in an achievable way with an extremely reliable machine. The C-arm linac is the primary workhorse in radiotherapy, so you have the best of everything.”
Time considerations
While online ART can take longer than conventional treatments, Evo’s use of automation and AI limits the additional time requirement to just five minutes – increasing the overall workflow from 12 to 17 minutes and remaining within the clinic’s standard time slots.
Elekta Evo Evo is a next-generation CT-Linac designed to improve access to adaptive radiotherapy. (Courtesy: Elekta)
The workflow begins with patient positioning and CBCT imaging, with Evo’s AI-enhanced Iris imaging significantly improving image quality, crucial when performing ART. The radiation therapist then matches the cone-beam and planning CTs and performs any necessary couch shift.
Simultaneously, Elekta ONE Online performs AI auto-contouring of OARs, which are reviewed by the physician, and the target volume is copied in. The physicist then simulates the dose distribution on the new contours, followed by a plan review. “Then you can decide whether to adapt or not,” says Lampe. “This is an outstanding feature.” The final stage is treatment delivery and online dosimetry.
When DTZ Berlin first began clinical treatments with Evo, some of Lampe’s colleagues were apprehensive as they were attached to the conventional workflow. “But now, with CBCT providing the chance to see what will be treated, every doctor on my team has embraced the shift and wouldn’t go back,” he says.
The first treatments were for prostate cancer, a common indication that’s relatively easy to treat. “I also thought that if the Elekta ONE workflow struggled, I could contour this on my own in a minute,” says Lampe. “But this was never necessary, the process is very solid. Now we also treat prostate cancer patients with lymph node metastases and those with relapse after radiotherapy. It’s a real success story.”
Lampe says that older and frailer patients may benefit the most from online ART, pointing out that while published studies often include relatively young, healthy patients, “our patients are old, they have chronic heart disease, they’re short of breath”.
For prostate cancer, for example, patients are instructed to arrive with a full bladder and an empty rectum. “But if a patient is in his eighties, he may not be able to do this and the volumes will be different every day,” Lampe explains. “With online adaptive, you can tell patients: ‘if this is not possible, we will handle it, don’t stress yourself’. They are very thankful.”
Making ART available to all
At UMC Utrecht in the Netherlands, the radiotherapy team has also added CT-Linac online adaptive to its clinical toolkit.
UMC Utrecht is renowned for its development of MR-guided radiotherapy, with physicists Bas Raaymakers and Jan Lagendijk pioneering the development of a hybrid MR-Linac. “We come from the world of MR-guidance, so we know that ART makes sense,” says Raaymakers. “But if we only offer MR-guided radiotherapy, we miss out on a lot of patients. We wanted to bring it to the wider community.”
ART for all The radiotherapy team at UMC Utrecht in the Netherlands has added CT-Linac online adaptive to its clinical toolkit. (Courtesy: UMC Utrecht)
At the time of speaking to Physics World, the team was treating its second patient with CBCT-guided ART, and had delivered about 30 fractions. Both patients were treated for bladder cancer, with future indications to explore including prostate, lung and breast cancers and bone metastases.
“We believe in ART for all patients,” says medical physicist Anette Houweling. “If you have MR and CT, you should be able to choose the optimal treatment modality based on image quality. For below the diaphragm, this is probably MR, while for the thorax, CT might be better.”
Ten minute target for OART
Houweling says that ART delivery has taken 19 minutes on average. “We record the CBCT, perform image fusion and then the table is moved, that’s all standard,” she explains. “Then the adaptive part comes in: delineation on the CBCT and creating a new plan with Elekta ONE Planning as part of Elekta One Online.”
The plan adaptation, when selected to perform, takes roughly four minutes to create a clinical-grade volumetric-modulated arc therapy (VMAT) plan. With the soon to be installed next-generation optimizer, it is expected to take less than one minute to generate a VMAT plan.
“As you start with the regular workflow, you can still decide not to choose adaptive treatment, and do a simple couch shift, up until the last second,” says Raaymakers. It’s very close to the existing workflow, which makes adoption easier. Also, the treatment slots are comparable to standard slots. Now with CBCT it takes 19 minutes and we believe we can get towards 10. That’s one of the drivers for cone-beam adaptive.”
Shorter treatment times will impact the decision as to which patients receive ART. If fully automated adaptive treatment is deliverable in a 10-minute time slot, it could be available to all patients. “From the physics side, our goal is to have no technological limitations to delivering ART. Then it’s up to the radiation oncologists to decide which patients might benefit,” Raaymakers explains.
Future gazing
Looking to the future, Raaymakers predicts that simulation-free radiotherapy will be adopted for certain standard treatments. “Why do you need days of preparation if you can condense the whole process to the moment when the patient is on the table,” he says. “That would be very much helped by online ART.”
“Scroll forward a few years and I expect that ART will be automated and fast such that the user will just sign off the autocontours and plan in one, maybe tune a little, and then go ahead,” adds Houweling. “That will be the ultimate goal of ART. Then there’s no reason to perform radiotherapy the traditional way.”
Imagine you had a bad breakup in college. Your ex-partner is furious and self-publishes a book that names you in its title. You’re so humiliated that you only dimly remember this ex, though the book’s details and anecdotes ring true.
According to the book, you used to be inventive, perceptive and dashing. Then you started hanging out with the wrong crowd, and became competitive, self-involved and incapable of true friendship. Your ex struggles to turn you around; failing, they leave. The book, though, is so over-the-top that by the end you stop cringing and find it a hoot.
After receiving his PhD in theoretical physics at the Technical University of Vienna in 2002, Grimstrup writes, he was “one of the young rebels” embarking on “a completely unexplored area” of theoretical physics, combining elements of loop quantum gravity and noncommutative geometry. But there followed a decade of rejected articles and lack of opportunities.
Grimstrup became “disillusioned, disheartened, and indignant” and in 2012 left the field, selling his flat in Copenhagen to finance his work. Grimstrup says he is now a “self-employed researcher and writer” who lives somewhere near the Danish capital. You can support him either through Ko-fi or Paypal.
Fomenting fear
The Ant Mill opens with a copy of the first page of the letter that Grimstrup’s fellow Dane Niels Bohr sent in 1917 to the University of Copenhagen successfully requesting a four-storey building for his physics institute. Grimstrup juxtaposes this incident with the rejection of his funding request, almost a century later, by the Danish Council for Independent Research.
Today, he writes, theoretical physics faces a situation “like the one it faced at the time of Niels Bohr”, but structural and cultural factors have severely hampered it, making it impossible to pursue promising new ideas. These include Grimstrup’s own “quantum holonomy theory, which is a candidate for a fundamental theory”. The Ant Mill is his diagnosis of how this came about.
The Standard Model of particle physics, according to Grimstrup, is dominated by influential groups that squeeze out other approaches.
A major culprit, in Grimstrup’s eyes, was the Standard Model of particle physics. That completed a structure for which theorists were trained to be architects and should have led to the flourishing of a new crop of theoretical ideas. But it had the opposite effect. The field, according to Grimstrup, is now dominated by influential groups that squeeze out other approaches.
The biggest and most powerful is string theory, with loop quantum gravity its chief rival. Neither member of the coterie can make testable predictions, yet because they control jobs, publications and grants they intimidate young researchers and create what Grimstrup calls an “undercurrent of fear”. (I leave assessment of this claim to young theorists.)
Grimstrup says that the reviewers and editors of these journals told him that his papers variously lacked concrete physical results, were exercises in mathematics, seemed the same as other papers, or lacked “relevance and significance”. Grimstrup sees this as the coterie’s handiwork, for such journals are full of string theory papers open to the same criticism.
“Science is many things,” Grimstrup writes at the end. “[S]imultaneously boring and scary, it is both Indiana Jones and anonymous bureaucrats, and it is precisely this diversity that is missing in the modern version of science”. What the field needs is “courage…hunger…ambition…unwillingness to compromise…anarchy.”
Grimstrup hopes that his book will have an impact, helping to inspire young researchers to revolt, and to make all the scientific bureaucrats and apparatchiks and bookkeepers and accountants “wake up and remember who they truly are”.
The critical point
The Ant Mill is an example of what I have called “rant literature” or rant-lit. Evangelical, convinced that exposing truth will make sinners come to their senses and change their evil ways, rant lit can be fun to read, for it is passionate and full of florid metaphors.
Theoretical physicists, Grimstrup writes, have become “obedient idiots” and “technicians”. He slams theoretical physics for becoming a “kingdom”, a “cult”, a “hamster wheel”, and “ant mill”, in which the ants march around in a pre-programmed “death spiral”.
Grimstrup hammers away at theories lacking falsifiability, but his vehemence invites you to ask: “Is falsifiability really the sole criterion for deciding whether to accept or fail to pursue a theory?”
An attentive reader, however, may come away with a different lesson. Grimstrup calls falsifiability the “crown jewel of the natural sciences” and hammers away at theories lacking it. But his vehemence invites you to ask: “Is falsifiability really the sole criterion for deciding whether to accept or fail to pursue a theory?”
In his 2013 book String Theory and the Scientific Method, for instance, the Stockholm University philosopher of science Richard Dawid suggested rescuing the scientific status of string theory by adding such non-empirical criteria to evaluating theories as clarity, coherence and lack of alternatives. It’s an approach that both rescues the formalistic approach to the scientific method and undermines it.
Dawid, you see, is making the formalism follow the practice rather than the other way around. In other words, he is able to reformulate how we make theories because he already knows how theorizing works – not because he only truly knows what it is to theorize after he gets the formalism right.
Grimstrup’s rant, too, might remind you of the birth of the Yang–Mills theory in 1954. Developed by Chen Ning Yang and Robert Mills, it was a theory of nuclear binding that integrated much of what was known about elementary particle theory but implied the existence of massless force-carrying particles that then were known not to exist. In fact, at one seminar Wolfgang Pauli unleashed a tirade against Yang for proposing so obviously flawed a theory.
The theory, however, became central to theoretical physics two decades later, after theorists learned more about the structure of the world. The Yang-Mills story, in other words, reveals that theory-making does not always conform to formal strictures and does not always require a testable prediction. Sometimes it just articulates the best way to make sense of the world apart from proof or evidence.
The lesson I draw is that becoming the target of a rant might not always make you feel repentant and ashamed. It might inspire you into deep reflection on who you are in a way that is insightful and vindicating. It might even make you more rather than less confident about why you’re doing what you’re doing
The term dark energy, first used in 1998, is a proposed form of energy that affects the universe on the largest scales. Its primary effect is to drive the accelerating expansion of the universe – an observation that was awarded the 2011 Nobel Prize in Physics.
Dark energy is now a well established concept and forms a key part of the standard model of Big Bang cosmology, the Lambda-CDM model.
The trouble is, we’ve never really been able to explain exactly what dark energy is, or why it has the value that it does.
Even worse, new data acquired by cutting-edge telescopes have suggested that dark energy might not even exist as we had imagined it.
This is where the new work by Mukherjee and Sen comes in. They combined two of these datasets, while making as few assumptions as possible, to understand what’s going on.
The first of these datasets came from baryon acoustic oscillations. These are patterns in the distribution of matter in the universe, created by sound waves in the early universe.
The second dataset is based on a survey of supernovae data from the last 5 years. Both sets of data can be used to track the expansion history of the universe by measuring distances at different snapshots in time.
The team’s results are in tension with the Lambda-CDM model at low redshifts. Put simply, the results disagree with the current model at recent times. This provides further evidence for the idea that dark energy, previously considered to have a constant value, is evolving over time.
The tension in the expansion rate is most evident at low redshifts (Courtesy: P. Mukherjee)
The is far from the end of the story with dark energy. New observational data, and new analyses such as this one are urgently required to provide a clearer picture.
However, where there’s uncertainty, there’s opportunity. Understanding dark energy could hold the key to understanding quantum gravity, the Big Bang and the ultimate fate of the universe.
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